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Interferon in systemic lupus erythematosus-A halfway between monogenic autoinflammatory and autoimmune disease.
Heliyon
November 2022
University of Medicine and Pharmacy Carol Davila, Dionisie Lupu Street, Number 37, Postal Code 020021, Bucharest, Romania.
Although perceived as an adaptative immune disorder, mainly related to Lymphocyte B and T, last years focus on Systemic Lupus Erythematosus (SLE) pathogeny emphasised the important role of innate immunity. This should not take us by surprise since the lupus cell described by Hargraves and colleagues in 1948 was a neutrophil or macrophage with specific aspect after coloration with haematoxylin related to cell detritus engulfment (Hargraves et al., 1948) [1] ( 1948, Proc Staff Meet Mayo Clinic, pp.
View Article and Find Full Text PDFThe Human Gut Phageome: Origins and Roles in the Human Gut Microbiome.
Front Cell Infect Microbiol
July 2021
School of Life Sciences, The University of Warwick, Coventry, United Kingdom.
The investigation of the microbial populations of the human body, known as the microbiome, has led to a revolutionary field of science, and understanding of its impacts on human development and health. The majority of microbiome research to date has focussed on bacteria and other kingdoms of life, such as fungi. Trailing behind these is the interrogation of the gut viruses, specifically the phageome.
View Article and Find Full Text PDFDiagnosis of systemic lupus erythematosus by presence of Hargraves cells in eosinophilic pleural effusion: Case report.
Medicine (Baltimore)
October 2018
Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland.
Rationale: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections.
Patient Concerns: In rare cases, pleural eosinophilia is associated with connective tissue disease.
Diagnoses: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997.
Predictive Behavior of a Computational Foot/Ankle Model through Artificial Neural Networks.
Comput Math Methods Med
March 2017
Department of Biomedical Engineering, Virginia Commonwealth University, 401 West Main Street, P.O. Box 843067, Richmond, VA 23284-3067, USA.
Computational models are useful tools to study the biomechanics of human joints. Their predictive performance is heavily dependent on bony anatomy and soft tissue properties. Imaging data provides anatomical requirements while approximate tissue properties are implemented from literature data, when available.
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