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Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients.
BMC Anesthesiol
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, 310006, China.
Background: Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of action, and quick and smooth recovery. However, the pharmacokinetic characteristics of continuous infusions and the correlation between the plasma concentration and the bispectral index (BIS) in elderly patients are still unknown.
Method: In this randomized, controlled study, thirty elderly patients (62-78 years old) undergoing elective gastrointestinal tumor resection were treated with propofol (N = 15) or ciprofol (N = 15) as sedatives during anesthesia.
The effect of dexmedetomidine on acute kidney injury after elective major abdominal surgery : a retrospective single-center propensity score matched study.
BMC Anesthesiol
December 2024
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Major abdominal surgery is a kind of high-risk surgery type for postoperative acute kidney injury (AKI) among non-cardiac surgeries. Despite dexmedetomidine exerts significant renal protective effects in cardiac surgeries and animal studies, whether it is associated with a lower incidence of AKI in major abdominal surgeries remains unclear.
Methods: From January 2019 to July 2021, patients undergoing elective major abdominal surgery in West China Hospital were enrolled.
Using Legitimation Code Theory to Underpin the Development of Undergraduate Nursing Students' Breastfeeding Knowledge: A Qualitative Study.
J Adv Nurs
December 2024
School of Nursing, University of Wollongong, Wollongong, Australia.
Aim: To explore how undergraduate nursing students develop knowledge during a breastfeeding module.
Design: A qualitative study using a single case-study approach.
Methods: This study was conducted in Australia over 2 years during the period between July 2021 and December 2022.
The Effect of Dimethyl Sulfoxide on the Microtensile Bond Strength of Universal Adhesives to Dentin.
Front Dent
September 2024
Department of Esthetic and Restorative Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
The goal of this investigation was to see how a dentin pretreatment with 5% DMSO affected the microtensile bond strength (μTBS) of universal adhesives. In terms of adhesive kind and etching procedure, 32 healthy third human molars were randomly separated into eight groups. Three universal adhesives with etch-and-rinse and self-etch strategies (G-Premio Bond: GPB.
View Article and Find Full Text PDFEndometriosis leading to frequent emergency department visits-women's experiences and perspectives.
PLoS One
November 2024
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Background: Endometriosis is a common condition affecting 1-10% of all women. The condition is highly associated with pain. Most women with endometriosis are treated as elective outpatients, but these patients sometimes need to visit the emergency department.
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