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Optimization of antiviral dosing in Herpesviridae encephalitis: a promising approach to improve outcome?
Clin Microbiol Infect
December 2024
Institute of Medical Microbiology and Virology, University Medical Center, Göttingen, Germany.
Background: Despite established antiviral therapy for herpes simplex virus, varicella zoster and cytomegalovirus encephalitis, the outcome remains poor.
Objectives: To assess pharmacokinetic (PK) and pharmacodynamic (PD) data of antiviral drugs in the central nervous system (CNS) to optimize the treatment of Herpesviridae encephalitis.
Sources: PUBMED search 1950 to September 2024, terms (1) "encephalitis" and ("HSV" or "VZV" or "CMV") or (2) cerebrospinal and ("(val)acyclovir" or "(val)ganciclovir" or "foscarnet" or "cidofovir").
Local recurrences after DIEP reconstruction of the breast - Epidemiology and strategies for treatment.
J Plast Reconstr Aesthet Surg
January 2025
Department of Plastic Surgery, Sana Hospital Gerresheim, Gräulinger Str. 120, 40625 Düsseldorf, Germany; In cooperation with the Faculty of Health at Witten/Herdecke University, Germany. Electronic address:
Article Synopsis
- Breast cancer is the most prevalent cancer among women, and breast reconstruction can utilize either autologous fat tissue, implants, or both, with no increased risk of cancer recurrence after reconstruction compared to mastectomy alone.
- The study aimed to assess the recurrence rates following deep inferior epigastric perforator (DIEP) flap reconstruction and share experiences in managing any local recurrences.
- A total of 666 patients underwent DIEP flap reconstruction across two breast centers, revealing a 2% recurrence rate, with options for tumor resection while preserving the DIEP flap.
Detecting Clinically Significant Prostate Cancer in PI-RADS 3 Lesions Using T2w-Derived Radiomics Feature Maps in 3T Prostate MRI.
Curr Oncol
November 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Prostate Imaging Reporting and Data System version 2.1 (PI-RADS) category 3 lesions are a challenge in the clinical workflow. A better detection of the infrequently occurring clinically significant prostate cancer (csPCa) in PI-RADS 3 lesions is an important objective.
View Article and Find Full Text PDFPrediction of anastomotic insufficiency based on the mucosal microbiome prior to colorectal surgery: a proof-of-principle study.
Sci Rep
July 2024
Clinic and Polyclinic for Visceral, Transplant, Thoracic and Vascular Surgery, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Anastomotic leakage (AL) is a potentially life-threatening complication following colorectal cancer (CRC) resection. In this study, we aimed to unravel longitudinal changes in microbial structure before, during, and after surgery and to determine if microbial alterations may be predictive for risk assessment between sufficient anastomotic healing (AS) and AL prior surgery. We analysed the microbiota of 134 colon mucosal biopsies with 16S rRNA V1-V2 gene sequencing.
View Article and Find Full Text PDFInjection of Autologous Adipose Stromal Vascular Fraction in Combination with Autologous Conditioned Plasma for the Treatment of Advanced Knee Osteoarthritis Significantly Improves Clinical Symptoms.
J Clin Med
May 2024
Department of Trauma and Orthopaedic Surgery, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University, Burgsteig 13, 33617 Bielefeld, Germany.
(1) Osteoarthritis (OA) is the most common joint disease in the world. It is chronic, systemic, progressive and disabling. Orthobiologics have the potential to positively alter the course of this disease.
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