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Isolation of Myenteric and Submucosal Plexus from Mouse Gastrointestinal Tract and Subsequent Co-Culture with Small Intestinal Organoids.
Cells
May 2024
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Intestinal homeostasis results from the proper interplay among epithelial cells, the enteric nervous system (ENS), interstitial cells of Cajal (ICCs), smooth muscle cells, the immune system, and the microbiota. The disruption of this balance underpins the onset of gastrointestinal-related diseases. The scarcity of models replicating the intricate interplay between the ENS and the intestinal epithelium highlights the imperative for developing novel methods.
View Article and Find Full Text PDFImproving morphological and functional properties of enteric neuronal networks in vitro using a novel upside-down culture approach.
Am J Physiol Gastrointest Liver Physiol
May 2024
Department of Informatics and Microsystems Technology, University of Applied Sciences Kaiserslautern, Zweibrücken, Germany.
The enteric nervous system (ENS) comprises millions of neurons and glia embedded in the wall of the gastrointestinal tract. It not only controls important functions of the gut but also interacts with the immune system, gut microbiota, and the gut-brain axis, thereby playing a key role in the health and disease of the whole organism. Any disturbance of this intricate system is mirrored in an alteration of electrical functionality, making electrophysiological methods important tools for investigating ENS-related disorders.
View Article and Find Full Text PDFCharacterization of risks and pathogenesis of respiratory diseases caused by rural atmospheric PM.
Sci Total Environ
March 2024
Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan, China; Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, China. Electronic address:
Forty-six percent of the world's population resides in rural areas, the majority of whom belong to vulnerable groups. They mainly use cheap solid fuels for cooking and heating, which release a large amount of PM and cause adverse effects to human health. PM exhibits urban-rural differences in its health risk to the respiratory system.
View Article and Find Full Text PDFThe challenge of FIGO type 3 leiomyomas and infertility: Exploring therapeutic alternatives amidst limited scientific certainties.
Int J Gynaecol Obstet
June 2024
1st Unit of Obstetrics and Gynecology, Department of Interdisciplinary Medicine (DIM), University of Bari, Bari, Italy.
Article Synopsis
- Uterine leiomyomas (ULs) are common non-cancerous tumors in women, but how they affect fertility is still not well understood.
- A new classification system from 2008 helps categorize these fibroids better, especially focusing on a special type called "type 3 UL" that can cause more problems for women trying to get pregnant.
- This review aims to explain how type 3 ULs can affect fertility and explore ways to treat them better, since there's not much solid information available right now.
Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women in reproductive age require specific management of the disease regarding both the course of the disease and treatment options.
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