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A Scoping Review of Pakistani Healthcare Simulation: Insights for Lower-Middle-Income Countries.
Cureus
December 2024
Research, Shifa Tameer-E-Millat University, Islamabad, PAK.
Healthcare simulation has gained global recognition in health professions education, yet its adoption in Pakistan, a lower-middle-income country (LMIC), remains limited. This scoping review aimed to explore how simulation is integrated into healthcare education in Pakistan, highlighting challenges and opportunities to inform similar LMICs. Pakistan serves as a critical case study for LMICs due to its unique challenges, including uneven access to simulation technologies and limited faculty training, which are shared by many similar resource-constrained settings.
View Article and Find Full Text PDFNationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study).
Front Immunol
January 2025
Department of Head and Neck Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka, Japan.
Background: Nivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, the limited rates of long-term survivors (< 20%) demand a robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify a plasma exosome (PEX) mRNA signature, which serves as a companion diagnostic of nivolumab and provides a biological clue to develop effective therapies for a majority of non-survivors.
View Article and Find Full Text PDFEffectiveness of three machine learning models for prediction of daily streamflow and uncertainty assessment.
Water Res X
May 2025
Institute for Artificial Intelligence R&D of Serbia, Fruškogorska 1, Novi Sad 21000, Serbia.
This study evaluates three Machine Learning (ML) models-Temporal Kolmogorov-Arnold Networks (TKAN), Long Short-Term Memory (LSTM), and Temporal Convolutional Networks (TCN)-focusing on their capabilities to improve prediction accuracy and efficiency in streamflow forecasting. We adopt a data-centric approach, utilizing large, validated datasets to train the models, and apply SHapley Additive exPlanations (SHAP) to enhance the interpretability and reliability of the ML models. The results show that TKAN outperforms LSTM but slightly lags behind TCN in streamflow forecasting.
View Article and Find Full Text PDFShort and mid-term research priorities for Veterans with multiple sclerosis: A modified Delphi process engaging Veterans, researchers, and operational partners.
Mult Scler Relat Disord
January 2025
Multiple Sclerosis Center of Excellence West, Veterans Affairs, USA; Rehabilitation Care Service, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington, 98108, USA; Department of Rehabilitation Medicine, University of Washington, 325 9th Avenue, Seattle, Washington, 98104, USA. Electronic address:
Background/objective: Identifying research priorities of Veterans, MS researchers, and key stakeholders is critical to advance high-quality, evidence-based, and Veteran-specific MS care.
Methods: We used a modified Delphi approach to identify research priorities for Veterans with MS. Electronic surveys were distributed to Veterans with MS (n = 50,975), MS researchers (n = 191), VA healthcare providers (1,337), and funding agency representatives (n = 6) asking about their 2-3 most important research questions that would benefit Veterans with MS for researchers to answer in the next 5-10 years.
Building resilience against cholera: lessons from the implementation of integrated community strategy for cholera control in Zambia.
BMJ Glob Health
January 2025
World Health Organization, Nairobi, Kenya.
Cholera has remained a persistent public health challenge in Zambia since the country's first reported outbreak in 1977. The recent outbreak, which began in October 2023 and is ongoing as of June 2024, is the most severe in Zambia's history and part of the larger 2022-2024 Southern Africa cholera outbreak, which has affected multiple countries in the region. This article describes the implementation of the integrated community strategy for cholera control (ICSCC) in three districts of the Copperbelt Province during this outbreak.
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