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A randomized trial of low-dose thrombolysis, ultrasound-assisted thrombolysis, or heparin for intermediate-high risk pulmonary embolism-the STRATIFY trial: design and statistical analysis plan.
Trials
December 2024
Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Background: Intermediate-high risk pulmonary embolism (PE) carries a significant risk of hemodynamic deterioration or death. Treatment should balance efficacy in reducing clot burden with the risk of complications, particularly bleeding. Previous studies on high-dose, short-term thrombolysis with alteplase (rtPA) showed a reduced risk of hemodynamic deterioration but no change in mortality and increased bleeding complications.
View Article and Find Full Text PDFMulti-Energy Evaluation of Image Quality in Spectral CT Pulmonary Angiography Using Different Strength Deep Learning Spectral Reconstructions.
Acad Radiol
December 2024
Radiomics and Augmented Intelligence Laboratory (RAIL), Department of Radiology and the Norman Fixel Institute for Neurological Diseases, University of Florida College of Medicine, Gainesville, FL (M.H-S., H.S.S., A.G.R., S.E.M., J.C.P., E.Y.A., B.H., R.F.); Department of Radiology, University of Florida College of Medicine, Gainesville, FL (M.H-S., H.S.S., A.G.R., J.C.P., E.Y.A., B.H., R.F.); Division of Medical Physics, University of Florida College of Medicine, Gainesville, FL (R.F.); Department of Neurology, Division of Movement Disorders, University of Florida College of Medicine, Gainesville, FL (R.F.); Department of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada (R.F.); Department of Radiology, AdventHealth Medical Group, Maitland, FL (R.F.). Electronic address:
Rationale And Objectives: To evaluate and compare image quality of different energy levels of virtual monochromatic images (VMIs) using standard versus strong deep learning spectral reconstruction (DLSR) on dual-energy CT pulmonary angiogram (DECT-PA).
Materials And Methods: A retrospective study was performed on 70 patients who underwent DECT-PA (15 PE present; 55 PE absent) scans. VMIs were reconstructed at different energy levels ranging from 35 to 200 keV using standard and strong levels with deep learning spectral reconstruction.
Early Lung Adenocarcinoma Manifesting as Irregular Subsolid Nodules: Clinical and CT Characteristics.
Acad Radiol
December 2024
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China (P.-l.Z., T.-y.L., F.-j.L., Q.L.). Electronic address:
Rationale And Objectives: To explore the clinical and computed tomography (CT) characteristics of early-stage lung adenocarcinoma (LADC) that presents with an irregular shape.
Materials And Methods: The CT data of 575 patients with stage IA LADC and 295 with persistent inflammatory lesion (PIL) manifesting as subsolid nodules (SSNs) were analyzed retrospectively. Among these patients, we selected 233 patients with LADC and 140 patients with PIL, who showed irregular SSNs, hereinafter referred to as irregular LADC (I-LADC) and irregular PIL (I-PIL), respectively.
Development and Validation of a Nomogram Based on Multiparametric MRI for Predicting Lymph Node Metastasis in Endometrial Cancer: A Retrospective Cohort Study.
Acad Radiol
December 2024
Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China (Y.T., Y.W., Y.Y., X.Q., Y.H., J.L.); Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning 530021, Guangxi Zhuang Autonomous Region, PR China (J.L.). Electronic address:
Rationale And Objectives: To develop a radiomics nomogram based on clinical and magnetic resonance features to predict lymph node metastasis (LNM) in endometrial cancer (EC).
Materials And Methods: We retrospectively collected 308 patients with endometrial cancer (EC) from two centers. These patients were divided into a training set (n=155), a test set (n=67), and an external validation set (n=86).
Dynamic Metabolic Characterization of Lung Tissues in Rats Exposed to Whole-Thorax Irradiation Based on GC-MS.
Biomed Chromatogr
January 2025
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
An animal model of radiation-induced lung injury (RILI) was established using female rats given sublethal whole-thorax X-ray irradiation (15 Gy) at a dose rate of 2.7 Gy/min. The rats were studied for up to day 45 and compared with sham-irradiated controls.
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