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Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.
Int J Clin Pharm
January 2025
Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei Economic and Technological Development District, Hefei, Anhui, China.
Background: The analgesic efficacy of esketamine combined with butorphanol in thoracoscopic surgery remains unclear.
Aim: This study explored the effects of perioperative esketamine combined with butorphanol versus butorphanol alone on acute and chronic postoperative pain in patients who underwent video-assisted lobectomy.
Method: A total of 181 patients were enrolled, with 90 in the esketamine-butorphanol group (Group BK) receiving intraoperative esketamine infusion and postoperative patient-controlled intravenous analgesia (PCIA) (esketamine 1.
Blood loss in one-stage bilateral total knee arthroplasty: cruciate-retaining vs. posterior stabilized. A propensity score-matched analysis.
SICOT J
December 2024
Department of Orthopaedics, Faculty of Medicine, Naresuan University, 99 Moo 9, Phitsanulok-Nakohn Sawan Road, Mueang District, Phitsanulok, Thailand.
Introduction: Although single-stage bilateral total knee arthroplasty (BTKA) presents several advantages, higher perioperative blood loss is a potentiate drawback that is still inevitable. Cruciate retaining (CR) TKA may theoretically result in less blood loss, offer better proprioception, and more physiologic kinematics compared to posterior stabilized (PS) TKA. The objective of this study was to compare perioperative blood loss and recovery among patients who underwent CR and PS BTKA.
View Article and Find Full Text PDFImpact of Dexmedetomidine-Based Opioid-Sparing Anesthesia on Opioid Use After Minimally Invasive Repair of Pectus Excavatum: A Prospective Randomized Controlled Trial.
J Clin Med
November 2024
Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Article Synopsis
- Opioid-sparing anesthesia (OSA) using dexmedetomidine reduces postoperative pain and opioid consumption compared to traditional opioid-based anesthesia (OBA) in patients undergoing pectus excavatum repair.
- The study involved 84 patients, showing that those in the OSA group required significantly less morphine-equivalent medication and reported lower pain scores in the first 48 hours after surgery.
- Recovery times and overall stability during the procedure were similar between the two groups, indicating that OSA is a safe and effective alternative to OBA.
An Improved GC-MS/MS Method for a Fast Multidrug Analysis in Hair.
Drug Test Anal
December 2024
Analytical Toxicology Laboratory, Analytical Toxicology Division, Health Sciences Authority, Singapore.
This study presents the development and validation of a drug testing method in hair, employing a semi-automated sample preparation procedure and gas chromatography-tandem mass spectrometry (GC-MS/MS) for simultaneous multidrug analysis in hair. The method aims to detect and quantify multiple drugs in hair, including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, ketamine, norketamine, cocaine, benzoylecgonine, morphine, codeine and 6-monoacetylmorphine, using a comprehensive procedure involving decontamination, pulverization, clean-up using supported-liquid extraction (SLE) and a two-step derivatization process. The method validation included specificity, linearity, limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, carryover, robustness and stability.
View Article and Find Full Text PDFAtypical Clinical Presentation of Hypothermia Induced by Intrathecal Morphine in a Patient Who Underwent Total Knee Arthroplasty Under Spinal Anesthesia: A Case Report.
Cureus
November 2024
Department of Anesthesia and Perioperative Medicine, London Health Sciences Centre, and St. Joseph Health Care, Lawson Health Research Institute, Schulich School of Medicine and Dentistry, Western University, London, CAN.
This case report describes a 62-year-old male who experienced paradoxical hypothermia following an elective total knee replacement (TKR) performed under spinal anesthesia with intrathecal morphine administration. The patient presented with significant hypothermia, defined as a body temperature below 35°C, approximately 45 minutes following the administration of anesthesia. The condition demonstrated resistance to conventional rewarming techniques.
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