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Genetically engineered gas vesicle proteins with proliferative potential for synergistic targeted tumor therapy.
RSC Adv
January 2025
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University Chongqing 400016 China +86-13708302390.
Nanomedicine enables precision-targeted therapies through a non-invasive approach, and nanoparticles may be biologically affected during their colonization . Ensuring the efficient expression of their performance , while ensuring biosafety, is of great significance. Previous studies have employed genetically engineered following entry as a genetically engineered targeting synergist, to enhance the effect of focused ultrasound ablation by exploiting its targeted colonization of tumor tissue.
View Article and Find Full Text PDFAssessment of Coronary Microcirculation with High Frame-Rate Contrast-Enhanced Echocardiography.
Ultrasound Med Biol
January 2025
Biomedical Engineering, Cardiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands; Medical Imaging, Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands. Electronic address:
Objective: Assessing myocardial perfusion in acute myocardial infarction is important for guiding clinicians in choosing appropriate treatment strategies. Echocardiography can be used due to its direct feedback and bedside nature, but it currently faces image quality issues and an inability to differentiate coronary macro- from micro-circulation. We previously developed an imaging scheme using high frame-rate contrast-enhanced ultrasound (HFR CEUS) with higher order singular value decomposition (HOSVD) that provides dynamic perfusion and vascular flow visualization.
View Article and Find Full Text PDFPreliminary application of EPID three-dimensional dose reconstruction in in vivo dose verification of breast cancer intensity-modulated radiation therapy.
Phys Med
January 2025
Department of Radiation Oncology, The Third Affiliated Hospital, Sun Yan-Sen University, Guangzhou 510630, China. Electronic address:
A preliminary study was conducted using electronic portal imaging device (EPID) based dose verification in pre-treatment and in vivo dose reconstruction modes for breast cancer intensity-modulated radiation therapy (IMRT) technique with known repositioning set-up errors. For 43 IMRT plans, the set-up errors were determined from 43 sets of EPID images and 258 sets of cone beam computed tomography images. In-house developed Edose software was used to reconstruct the dose distribution using the pre-treatment and on-treatment (in vivo) EPID acquired fluence maps.
View Article and Find Full Text PDFExploring the binomial BALB/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of Thor strain subpopulations.
Exp Parasitol
December 2024
Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Rio de Janeiro, RJ, Brazil. Electronic address:
Article Synopsis
- Leishmania (Viannia) braziliensis causes various types of leishmaniasis, and the study investigates how different subpopulations (Thor03, Thor10, Thor22) affect disease progression in BALB/c mice.
- The research found that after three weeks of infection, Thor03 and Thor10 led to larger lesions and influenced immune response markers, showing lower IL-12 and TNF levels, while Thor10 had the highest IL-10 levels.
- The study concluded that these subpopulations might lead to mild footpad lesions but can persist in lymph nodes, highlighting differences in infection patterns and immune responses among the subpopulations.
Synthesis of MR fingerprinting information from magnitude-only MR imaging data using a parallelized, multi network U-Net convolutional neural network.
Front Radiol
December 2024
Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Article Synopsis
- MR fingerprinting (MRF) is an innovative technique for measuring MR relaxometry with high precision, but its complex data requirements hinder its widespread use.
- A deep learning (DL) network, specifically a U-Net, was created to synthesize MRF signals from regular magnitude-only MRI data collected from 37 volunteers, comparing the results with actual acquired MRF signals.
- The study found strong concordance between synthesized and actual MRF data, indicating that DL can enable quantitative relaxometry without the need for specialized MRF pulse sequences.
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