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Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing.
Sci Rep
January 2025
Fischell Department of Bioengineering, University of Maryland, College Park, USA.
The development of optical sensors for label-free quantification of cell parameters has numerous uses in the biomedical arena. However, using current optical probes requires the laborious collection of sufficiently large datasets that can be used to calibrate optical probe signals to true metabolite concentrations. Further, most practitioners find it difficult to confidently adapt black box chemometric models that are difficult to troubleshoot in high-stakes applications such as biopharmaceutical manufacturing.
View Article and Find Full Text PDFEnhanced detection of Cystatin C for predicting adverse outcomes in gestational diabetes mellitus using a point-of-care immunosensor.
Bioelectrochemistry
January 2025
Tongzhou Maternal & Child Health Hospital of Beijing, No. 124, Yuqiao Middle Road, Tongzhou District, Beijing 101101 PR China. Electronic address:
Cystatin C (Cys-C) is emerging as a critical biomarker for assess gestational diabetes mellitus (GDM), a condition that significantly impacts maternal and fetal health. In this study, we developed a novel label-free electrochemical immunosensor designed for point-of-care applications, offering lower reagent consumption and rapid detection of Cys-C in pregnant women with GDM. Compared to traditional enzyme-linked immunosorbent assays (ELISA), the sensor demonstrates enhanced sensitivity, reduced reagent usage, and faster detection.
View Article and Find Full Text PDFSerum iodine concentration in pregnant women and its association with thyroid function.
J Trace Elem Med Biol
January 2025
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China; Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. Electronic address:
Objective: This study aims to investigate the association of serum iodine concentration (SIC) with thyroid function-associated parameters in pregnant women in mild iodine deficient area, and explore its potential to predict individual iodine nutrition status in pregnant women.
Methods: A total of 741 pregnant women undergoing prenatal examinations in their second trimester at the Women's Hospital, Zhejiang University School of Medicine, from March 2021 to May 2022 were finally recruited into the study. Venous blood and morning urine were collected.
Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.
Am J Transl Res
December 2024
Department of Genetics and Endocrinology, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, Sichuan, China.
Objective: Evidence suggests that diethylhexyl phthalate (DEHP) may disrupt thyroid hormone homeostasis by targeting multiple components of the hypothalamic-pituitary-thyroid (HPT) axis, potentially harming human health. However, the relationship between DEHP exposure and thyroid function remains debated. We performed a meta-analysis to clarify the association between DEHP exposure and thyroid function.
View Article and Find Full Text PDFThe influence of xeno-free culture conditions on the angiogenic and adipogenic differentiation properties of adipose tissue-derived stem cells.
Regen Ther
June 2024
Department of Medical and Translational Biology, Umeå University, SE-901 87 Umeå, Sweden.
Introduction: Before performing cell therapy clinical trials, it is important to understand how cells are influenced by different growth conditions and to find optimal xeno-free medium formulations. In this study we have investigated the properties of adipose tissue-derived stem cells (ASCs) cultured under xeno-free conditions.
Methods: Human lipoaspirate samples were digested to yield the stromal vascular fraction cells which were then seeded in i) Minimum Essential Medium-α (MEM-α) supplemented with 10 % (v/v) fetal bovine serum (FBS), ii) MEM-α supplemented with 2 % (v/v) human platelet lysate (PLT) or iii) PRIME-XV MSC expansion XSFM xeno-free, serum free medium (XV).
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