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Association of objective subtle cognitive difficulties with amyloid-β and tau deposition compared to subjective cognitive decline.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Purpose: This study evaluated the differences in amyloid-β (Aβ), tau deposition, and longitudinal tau deposition between subjective cognitive decline (SCD) and objective subtle cognitive difficulties (Obj-SCD).
Methods: Participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (n = 234) and the Huashan cohort (n = 267) included individuals with Obj-SCD, SCD, subjective memory concern (SMC), and healthy controls (HC). General linear models (GLM) were used to compare baseline and longitudinal differences in Aβ and tau among the groups, and to examine the associations between these biomarkers.
Effects of bone metabolism on hematopoiesis: A Mendelian randomization study.
Osteoporos Sarcopenia
December 2024
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Objectives: Osteoblast is known to regulate hematopoiesis according to preclinical studies but the causal relationship in human remains uncertain. We aimed to evaluate causal relationships of bone mineral density (BMD) with blood cell traits using genetic data.
Methods: Summary statistics from the largest available genome-wide association study were retrieved for total body BMD (TBBMD), lumbar spine BMD (LSBMD), femoral neck BMD (FNBMD) and 29 blood cell traits including red blood cell, white blood cell and platelet-related traits.
Editorial: Methods and applications of tumour metabolic imaging in the preclinical and clinical setting.
Front Med (Lausanne)
January 2025
Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States.
Exercise-induced extracellular vesicles in reprogramming energy metabolism in cancer.
Front Oncol
January 2025
Laboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Cancer is caused by complex interactions between genetic, environmental, and lifestyle factors, making prevention strategies, including exercise, a promising avenue for intervention. Physical activity is associated with reduced cancer incidence and progression and systemic anti-cancer effects, including improved tumor suppression and prolonged survival in preclinical models. Exercise impacts the body's nutrient balance and stimulates the release of several exercise-induced factors into circulation.
View Article and Find Full Text PDFBeyond sleep: Rest and activity rhythm as a marker of preclinical and mild dementia in older adults with less education.
Neurobiol Sleep Circadian Rhythms
May 2025
Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
Background: Although sleep duration and sleep-related breathing disorders were associated with dementia previously, few studies examined the association between circadian rhythm association and cognitive status.
Objective: We aimed to investigate the association of rest and activity rhythm with cognitive performance in older people with cognitive complaints and less education.
Methods: Activity rhythm was evaluated with wrist actigraphy in 109 community-dwelling older people with cognitive complaints without diagnosed dementia.
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