Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0022-3913(69)90014-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An Overview of Predictive Biomarkers and Detection Approaches for Immunotherapy Response in GI Malignancies.
J Gastroenterol Hepatol
March 2025
Department of Radiology, Yunnan Cancer Center, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.
This review provides an in-depth exploration of the evolving role of immunotherapy in gastrointestinal (GI) cancers, with a particular focus on immune checkpoint inhibitors (ICIs) and their associated predictive biomarkers. We present a detailed analysis of established biomarkers, such as PD-L1, microsatellite instability (MSI), tumor mutational burden (TMB), and the tumor microenvironment (TME), as well as emerging biomarkers, including gut microbiota and Epstein-Barr virus (EBV). The predictive value of these biomarkers in guiding clinical decision-making and optimizing immunotherapy outcomes is thoroughly discussed.
View Article and Find Full Text PDFNanoFlora: Unveiling the therapeutic potential of Ipomoea aquatica nanoparticles.
J Genet Eng Biotechnol
March 2025
Karpagam College of Pharmacy, Coimbatore 641 032 Tamil Nadu, India; The Tamil Nadu Dr. M.G.R. Medical University, Chennai 600032 Tamil Nadu, India. Electronic address:
Introduction: Improving the pharmacokinetics of drugs is achieved through nano formulations and the role of natural product in the synthesis of nanomaterials is gaining prominence due to its eco-friendly nature, cost-effectiveness, and demonstrated efficacy. Metal nanoparticles (NPs) derived from Ipomoea aquatica Forsskal have been synthesized and evaluated for their antioxidant and antidiabetic properties towards enhancing the anticancer activity of the plant extracts.
Methodology: Hydroalcoholic extract was obtained from the entire Ipomoea aquatica plant and utilized as a key ingredient in the green synthesis of metal NPs.
Self-resistance-gene-guided, high-throughput automated genome mining of bioactive natural products from Streptomyces.
Cell Syst
March 2025
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Departments of Chemistry, Biochemistry, and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:
Natural products (NPs) from bacteria, fungi, and plants are a vital source of drug leads, with Streptomyces species being particularly significant due to their capability of producing diverse bioactive compounds. Here, we present a fully automated, scalable, high-throughput platform for discovering bioactive NPs in Streptomyces (FAST-NPS). This platform integrates computational biosynthetic gene cluster (BGC) prediction and prioritization guided by self-resistance genes, automated cloning and heterologous expression, high-throughput fermentation, and product extraction.
View Article and Find Full Text PDFBridging multi-level gaps: Bidirectional reciprocal cycle framework for text-guided label-efficient segmentation in echocardiography.
Med Image Anal
March 2025
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China. Electronic address:
Text-guided visual understanding is a potential solution for downstream task learning in echocardiography. It can reduce reliance on labeled large datasets and facilitate learning clinical tasks. This is because the text can embed highly condensed clinical information into predictions for visual tasks.
View Article and Find Full Text PDFA Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model.
J Cardiovasc Transl Res
March 2025
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic deterioration. To address this, a dual latex balloon catheter was designed for temporary closure and tested in a pig model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!