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Comparative Analysis of Preoperative Sedation Modalities: Oral Midazolam and Ketamine Versus Chloral Hydrate and Meperidine in Pediatric Tonsillectomy - A Randomized Clinical Trial.
Turk Arch Otorhinolaryngol
January 2025
Shiraz University of Medical Sciences, Anesthesiology and Critical Care Research Center, Shiraz, Iran.
Objective: A pre-anesthetic medication that is ideal for pediatric patients undergoing tonsillectomy should alleviate pediatric anxiety, facilitate the smooth induction of anesthesia, and have an analgesic effect for postoperative care. This study compared the effectiveness of an oral combination of midazolam and ketamine (MK) with an oral combination of chloral hydrate and meperidine (CM) as premedication in pediatric patients undergoing tonsillectomy.
Methods: This double-blind clinical trial study was conducted with 68 pediatric patients scheduled to undergo tonsillectomy.
Insufficient Labor Epidural Analgesia Due to Asymptomatic Sacral Perineural Cyst: A Case Report.
Cureus
November 2024
Department of Anesthesiology, Adachi Hospital, Kyoto, JPN.
Lumbar epidural anesthesia is widely used for labor epidural analgesia (LEA), but it often results in insufficient analgesia in the sacral region. We report a case where we performed LEA using lumbar epidural anesthesia, and an asymptomatic sacral perineural cyst was considered the potential cause of inadequate analgesia in the sacral region. A 33-year-old primigravida was admitted with premature rupture of membranes.
View Article and Find Full Text PDFAcceptability of midazolam and melatonin as premedications for anxious children undergoing general anaesthesia: a qualitative interview study with children, caregivers and health professionals participating in the MAGIC trial.
Trials
December 2024
School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Background: The acceptability of a children's premedication, prior to general anaesthesia (GA), is fundamental to ensuring positive clinical- and patient-reported outcomes. Midazolam, the current standard premedication, is known to have an unfavourable side-effects profile and presents a degree of risk which is accepted due to a need for compliance. Melatonin is a functionally diverse hormone with anxiolytic properties that offer potential benefits over midazolam.
View Article and Find Full Text PDFRecently, intranasal dexmedetomidine (DEX) has been reported to be effective as a preanesthetic medication, mostly in healthy pediatric patients. We attempted to administer intranasal DEX premedication in this case to an adult patient with intellectual disability who previously had difficulty tolerating premedication with oral midazolam. Using an intranasal atomization delivery device (MAD Nasal, Teleflex), we administered 1.
View Article and Find Full Text PDFComparative Evaluation of Oral and Intranasal Administration of Midazolam as Preanesthetic Medication in Pediatric Dental Patients Treated under General Anesthesia.
Int J Clin Pediatr Dent
August 2024
Department of Pediatric and Preventive Dentistry, Government Dental College and Hospital, Jaipur, Rajasthan, India.
Article Synopsis
- The study investigates the effectiveness of midazolam administrated orally vs. intranasally as preanesthetic medication for children aged 2-6 undergoing general anesthesia.
- Results show both methods provide adequate sedation and minimal side effects, making them equally effective for easing children’s anxiety.
- The findings suggest that while both routes are viable, the oral route is preferable for pediatric patients in dental procedures.
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