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Background: The goal of this study was to compare video head impulse test, video-oculography, and clinical balance test changes induced by ethanol consumption, in order to acquire a model for acute bilateral vestibular syndrome.

Methods: Four healthy adult men and 5 healthy adult women were recruited as volunteers in the study. Initial video head impulse test, videooculography, and clinical balance test examinations were made.

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We ask how vestibular and optokinetic information is combined ("fused") when human subjects who are being passively rotated while viewing a stationary optokinetic pattern try to tell when they have reached a previously instructed angular displacement ("targeting task"). Inevitably such a task entices subjects to also draw on cognitive mechanisms such as past experience and contextual expectations. Specifically, because we used rotations of constant angular velocity, we suspected that they would resort, consciously or unconsciously, to extrapolation strategies even though they had no explicit knowledge of this fact.

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The thresholds of dark adapted RCS rats and controls were estimated from optokinetic responses to blue stimuli, and compared to thresholds derived from b-wave stimulus/response functions. The rats were tested at ages 25, 30 and 35 days, a period during which the RCS degeneration is evolving and normal retinal development is proceeding. At all ages the OKN thresholds of control rats were lower than those of the RCS rats, but only by age 30 days did b-wave thresholds discriminate RCS from controls.

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