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The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol.
ERJ Open Res
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Background: Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are prevalent disease complications in people with cystic fibrosis. These understudied comorbidities significantly impact quality of life. The impact of highly effective modulator therapy (HEMT) in young children with cystic fibrosis (YCwCF) on these disease complications is unknown.
View Article and Find Full Text PDFImpact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study.
PLoS One
September 2024
Department of Otolaryngology-Head and Neck Surgery, University of California, Los Angeles, Los Angeles, CA, United States of America.
Article Synopsis
- Cystic fibrosis (CF) is often complicated by chronic rhinosinusitis (CRS), and while medical treatments exist, they may not always be effective for some patients, leading to the need for endoscopic sinus surgery.
- This study aims to compare the outcomes of endoscopic sinus surgery versus continued medical treatment for individuals with CF and CRS, assessing various factors such as pulmonary function, quality of life, and depression.
- The research is underway across nine CF centers in the U.S., and findings will contribute to guidelines for treating CF patients with CRS.
Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis.
Int Forum Allergy Rhinol
November 2024
Department of Head and Neck Surgery, University of California, Los Angeles, California, USA.
Background: Sociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.
Methods: In a prospective, multi-institutional study, adult PwCF completed the 22-Question SinoNasal Outcome Test (SNOT-22), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R).
Predictors of Sinonasal Improvement After Highly Effective Modulator Therapy in Adults with Cystic Fibrosis.
Laryngoscope
September 2024
Department of Medicine, National Jewish Health, Denver, Colorado, U.S.A.
Article Synopsis
- The study aimed to identify factors that predict improvement in chronic rhinosinusitis symptoms, measured by the SNOT-22, after initiating highly effective modulator therapy in adults with cystic fibrosis.
- Data from 184 participants showed that worse initial SNOT-22 scores, having the F508del mutation, and not having prior modulator therapy were linked to greater symptom improvement post-therapy.
- The minimal clinically important difference (MCID) for the SNOT-22 in this population was determined to be 8.5 points, indicating significant symptom improvement, and the test demonstrated strong internal consistency.
Decreases in Rhinology Care Utilization by People with Cystic Fibrosis on Highly Effective Modulator Therapy.
Ann Otol Rhinol Laryngol
March 2024
Department of Head and Neck Surgery, University of California, Los Angeles, CA, USA.
Background: Many people with cystic fibrosis (PwCF) have chronic rhinosinusitis (CRS). CRS requires additional management beyond that of pulmonary disease and leads to increased utilization of healthcare resources. Elexacaftor/tezacaftor/ivacaftor (ETI) is a highly effective modulator therapy that has been shown to improve CRS in PwCF.
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