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Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway.
Phytomedicine
January 2025
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, PR China. Electronic address:
Background: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.
Purpose: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.
Alginate from Possesses Antioxidant Activity and Attenuates Systemic Inflammation via Downregulation of Pro-Inflammatory Cytokines.
Mar Drugs
October 2024
Department of Pharmacology, Toxicology, and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, Vasil Aprilov Str. 15A, 4002 Plovdiv, Bulgaria.
Alginates are anionic polysaccharides present in the cell walls of brown seaweeds. Various biological activities of alginate and its derivatives have been described. In this study, we assessed the potential of alginate obtained from (formerly ) to scavenge free radicals and function as a ferric ion reductor.
View Article and Find Full Text PDFWhy Do Things Burn? Elizabeth Fulhame's Challenge to the Antiphlogistic Theory of Combustion.
Ambix
November 2024
Science, Technology, Health and Society Program, University of Puget Sound, Tacoma, WA, USA.
Motivated by her interest in fabric arts, late-eighteenth-century British chemist Elizabeth Fulhame experimentally investigated whether cloths of gold, silver, and other metals could be made by chemical rather than mechanical processes. In contrast to other women studying science at this time, she not only published an original monograph under her own name that challenged both the phlogistic and antiphlogistic views of combustion but also proposed an alternative explanation for oxidation and reduction. Although her contemporaries widely cited her innovative research, her history is not well known, yet a careful analysis of her work provides further insights into the reception of the antiphlogistic theory and the challenges and limitations experienced by women in chemistry during this period.
View Article and Find Full Text PDFInflammation promotes solid tumor progression, but how regulatory mechanisms of inflammation may affect leukemia is less well studied. Using annexin A5 (ANXA5), a calcium-binding protein known for apoptosis, which we discovered to be differentially expressed in the bone marrow microenvironment (BMM) of mice with acute myeloid (AML) vs chronic myeloid leukemia, as a model system, we unravel here a circuit in which AML-derived tumor necrosis factor α (TNF-α) dose-dependently reduces ANXA5 in the BMM. This creates an inflammatory BMM via elevated levels of prostaglandin E2 (PGE2).
View Article and Find Full Text PDFAngiotensinergic effect of β-Caryophyllene on Lipopolysaccharide- induced systemic inflammation.
Biochem Biophys Res Commun
July 2024
Laboratorio de Investigación y Desarrollo Farmacéutico, Departamento de Farmacología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, 44430, Guadalajara, Jalisco, Mexico. Electronic address:
Renin-Angiotensin System (RAS) is a peptidergic system, canonically known for its role in blood pressure regulation. Furthermore, a non-canonical RAS regulates pathophysiological phenomena, such as inflammation since it consists of two main axes: the pro-inflammatory renin/(pro)renin receptor ((P)RR) axis, and the anti-inflammatory angiotensin-converting enzyme 2 (ACE2)/Angiotensin-(1-7) (Ang-(1-7))/Mas Receptor (MasR) axis. Few phytochemicals have shown to exert angiotensinergic and anti-inflammatory effects through some of these axes; nevertheless, anti-inflammatory drugs, such as phytocannabinoids have not been studied regarding this subject.
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