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| http://dx.doi.org/10.1073/pnas.60.2.394 | DOI Listing |
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Fracture resistance and marginal fit of three different overlay designs using advanced zirconia-reinforced lithium disilicate CAD/CAM material.
BMC Oral Health
January 2025
Department of Conservative Dentistry, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Conservative dentistry introduced modern restoration designs, contributing to the greater use of partial-coverage ceramic restorations. New strong bondable ceramic materials made fabricating partial coverage ceramic restorations easier to restore the badly destructed teeth.
Aim Of The Study: This study investigated the impact of three distinct overlay preparation designs on the marginal fit (both before and after thermal aging) and the fracture resistance of overlay restorations fabricated using advanced zirconia-reinforced lithium disilicate (ALD) CAD/CAM glass-ceramic blocks.
As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.
View Article and Find Full Text PDFGlass Ionomer Cement Restoration Technique for Severe Molar Incisor Hypomineralization.
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Brazilian Dental Association, all in Natal, Rio Grande do Norte, Brazil.
Article Synopsis
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The Grotte du Bison Neandertals (Arcy-sur-Cure, France).
J Hum Evol
December 2024
Univ. Paris 1 Panthéon-Sorbonne, Univ. Paris Ouest Nanterre La Défense, MSH Mondes-CNRS-Ministère de la Culture, ArScAn, UMR 7041, 92000, Nanterre, France.
The Grotte du Bison, in Arcy-sur-Cure (Yonne, France), yielded a large assemblage of 49 Neandertal remains from late Mousterian layers, offering critical insights for the study of Middle to Upper Paleolithic populations of Western Europe. Previous studies described the external morphology of 13 isolated teeth and a partial maxilla. Building on this previous work, the current study provides further descriptions and analyses of the remains, including one postcranial fragment, six cranial fragments, two maxillary fragments, and 40 isolated teeth.
View Article and Find Full Text PDFEnergy-Resolved Mass Spectrometry and Mid-Infrared Spectroscopy for Purity Assessment of a Synthetic Peptide Cyclised by Intramolecular Huisgen Click Chemistry.
Methods Protoc
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Univ Brest, CEMCA, CNRS, UMR 6521, 29238 Brest, France.
Cyclic peptides have higher stability and better properties as therapeutic agents than their linear peptide analogues. Consequently, intramolecular click chemistry is becoming an increasingly popular method for the synthesis of cyclic peptides from their isomeric linear peptides. However, assessing the purity of these cyclic peptides by mass spectrometry is a significant challenge, as the linear and cyclic peptides have identical masses.
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