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Altered expression of aromatase and estrogen receptors in adipose tissue from men with obesity or type 2 diabetes.
J Clin Endocrinol Metab
January 2025
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.
Objective: Obesity and insulin resistance in men are linked to decreased testosterone and increased estradiol (E2) levels. Aromatase (ARO) converts testosterone into E2, and this occurs mainly in adipose tissue in men. E2 acts through estrogen receptors ESR1 and ESR2, and they potentially affect development of type 2 diabetes (T2D).
View Article and Find Full Text PDFNipecotic Acid Ameliorates Letrozole Induced Poly Cystic Ovarian Syndrome in Female Virgin Wistar Rats by Modulating Hypothalamic-Pituitary-Gonadal (HPG) Axis Regulated by GABA.
Reprod Sci
January 2025
Era College of Pharmacy, Era University, Lucknow, Uttar Pradesh, India.
PCOS is a common endocrine disorder in women particularly in their reproductive age. GABA has been implicated in the pathogenesis of PCOS through its central role in the hypothalamus. Hence, in this study we investigated the effect of Nipecotic acid (NPA) in Letrozole induced PCOS in female Wistar rats as NPA has been proven as a GABA uptake inhibitor.
View Article and Find Full Text PDFPeripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity.
Toxicol Sci
November 2024
Neurological and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, CPHEA, ORD, U.S. EPA, RTP, NC.
We recently identified the herbicide oxyfluorfen as an inhibitor of iodide uptake by the sodium iodide symporter (NIS), a key step in thyroid hormone synthesis, using in vitro assays. We also observed a suppression of serum T4 and T3 in juvenile rats exposed orally to oxyfluorfen for 4-8 days. The purpose of the present study was to further evaluate effects of an extended 31-day oral exposure using a male pubertal rat study (15 to 500 mg/kg).
View Article and Find Full Text PDFLow protein uptake during peripuberty impairs the testis, epididymis, and spermatozoa in pubertal and adult rats.
J Dev Orig Health Dis
October 2024
Laboratory of Toxicology and Metabolic Disturbs of Reproduction, General Biology Department, Biological Sciences Center, State University of Londrina, Londrina, Brazil.
Article Synopsis
- - The study investigates how a 30-day low-protein diet affects the reproductive development of male rats, focusing on the impacts during critical growth periods.
- - Results show that the diet led to decreased testicular and epididymal weight, impaired sperm production, and various cellular changes, along with lower testosterone production.
- - Although some aspects, like testicular and epididymal weight and overall sperm function, improved after a recovery period, permanent histological and morphological issues in sperm cells remained due to the initial protein restriction.
Physiologically based toxicokinetic and toxicodynamic (PBTK-TD) modelling of cis-bifenthrin in Carassius auratus and Xenopus laevis accounting for reproductive toxicity.
Environ Res
December 2024
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Pyrethroid insecticides are a class of endocrine disruptors and are believed to exhibit reproductive toxicity to aquatic organisms. Pyrethroids are widely detected in aquatic environments and can accumulate in aquatic organisms, but studies on their accumulation and the associated reproductive toxicity in aquatic organisms are still limited. We utilized Carassius auratus and Xenopus laevis as models for fish and amphibians, respectively, and developed and validated a physiologically based toxicokinetic and toxicodynamic (PBTK-TD) model for adult fish and frogs exposed to typical pyrethroid pesticides cis-bifenthrin (cis-BF).
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