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The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial.
Elife
January 2025
Department of Neurosurgery, Washington University School of Medicine, Springfield, United States.
Background: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. However, the effects of taVNS on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated.
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Alzheimers Dement
December 2024
Huntington Medical Research Institutes, Pasadena, CA, USA.
Background: Stroop task is used to evaluate inhibition, a core executive function. Alpha Event-Related Desynchronization (ERD) from analysis of electroencephalogram (EEG) during Stroop task reflects brain interference processing. We previously reported different relationships between heart rate variability (HRV) and alpha ERD during Stroop task.
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Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: There is increasing need for noninvasive biomarkers of Alzheimer's Disease (AD) neuropathologic change for early detection and intervention through risk-factor modification and disease-modifying therapies. One such biomarker is the prediction of chronological age from routine clinical tests such as an electrocardiogram (EKG) to discriminate between observed biological age from chronological age for healthy aging. Deviation of true age from predicted age has been associated with heart failure, hypertension, and coronary heart disease.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Early autonomic function changes in Alzheimer's disease (AD) may represent a biomarker for early affective changes in prodromal disease. We report preliminary differences in metrics of heart rate variability (HRV) before and during routine cognitive testing.
Method: We enrolled 50 participants from the Wake Forest Alzheimer's Disease Research Center to wear continuous ECG devices during their visit to assess time and frequency domain based metrics of HRV over 5 minutes at rest and during cognitive testing.
Developing Topics.
Alzheimers Dement
December 2024
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin - Institute of Psychiatry and Psychotherapy, Berlin, Germany.
Background: Self-replicating amyloid beta (Aβ) oligomers are described to be synaptotoxic and responsible for reduced synaptic plasticity, impaired neuronal function and thus for development and progression of Alzheimer's disease (AD). The all-D-enantiomeric peptide PRI-002 was developed to disassemble toxic Aβ oligomers into harmless Aβ monomers, very similar to a chaperone. PRI-002 is expected to reduce neurotoxicity and to restore synaptic plasticity in early AD stages.
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