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Post-radiation xerostomia therapy with allogeneic mesenchymal stromal stem cells in patients with head and neck cancer: study protocol for phase I clinical trial.
Radiol Oncol
December 2023
Blood Transfusion Center of Slovenia, Ljubljana, Slovenia.
Background: Xerostomia is a common side effect of radiotherapy in patients with head and neck tumors that negatively affects quality of life. There is no known effective standard treatment for xerostomia. Here, we present the study protocol used to evaluate the safety and preliminary efficacy of allogeneic mesenchymal stromal stem cells (MSCs) derived from umbilical cord tissue.
View Article and Find Full Text PDFInvestigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures.
Turk J Med Sci
February 2023
Department of Nuclear Medicine, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.
Article Synopsis
- The study investigated the effects of taurine and aqueous garlic extract (AGE) on healing osteoporotic fractures in ovariectomized rats.
- The experiment involved 24 female rats divided into three groups (control, taurine, AGE), with healing assessed through various biological methods six weeks post-surgery.
- Results showed that both taurine and AGE enhanced bone healing compared to the control group, with taurine exhibiting significant improvements in bone formation indicators and osteoblastic activity.
Scintigraphic evaluation of remote pre-conditioning protection against unilateral renal ischemia/reperfusion injury in rats: a longitudinal study.
Int Urol Nephrol
November 2019
The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
Purpose: To determine the role of remote perconditioning (RPeC) on renal function and histology in an animal model of unilateral renal ischemia and reperfusion (IR) injury.
Methods: Rats were subjected to 60 min unilateral renal ischemia. RPeC protocol was the application of four cycles of 5 min IR of left femoral artery during renal ischemia.
Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: Characterization, pharmacokinetic and deposition study.
Mater Sci Eng C Mater Biol Appl
July 2019
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
The present study was to develop etoposide loaded solid lipid nanoparticles (SLN) and optimize it for effective ocular delivery to the posterior eye. SLN were prepared by melt-emulsification and ultrasonication technique. Etoposide loaded SLN were optimized by using three-factor three levels Box-Behnken design to establish the functional relationships between variables on responses of particle size, polydispersity index (PDI) and entrapment efficiency (EE).
View Article and Find Full Text PDFSickle cell diseases: What can nuclear medicine offer?
Hell J Nucl Med
July 2019
Nuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of the beta-globin chain of adult hemoglobin A, resulting in hemoglobin S (HbS). The homozygous HbS disease (HbSS), an autosomal recessive disorder, is the most common form and the Mediterranean area, along with sub-Saharian African and India, have the highest prevalence (1%-15%). In particular, Sicily with a prevalence of 2%-5%, is among the most interested regions.
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