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Clinical Efficacy of Intravenous Papaverine plus Ketorolac in the Emergency Treatment of Renal Colic: A Randomized, Double-blind Clinical Trial.
Iran J Med Sci
November 2024
Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Acute renal colic has been challenging and has brought many concerns for physicians and patients for centuries. This study aimed to evaluate the analgesic effect and safety of a combination of papaverine and ketorolac against ketorolac and placebo in treating acute renal colic.
Methods: This randomized clinical trial was performed in patients with renal colic from May 2018 to May 2020 in Ahvaz, Iran.
Symmetrical peripheral gangrene caused by urosepsis: Case reports and literature review.
Medicine (Baltimore)
October 2024
Department of Critical Care Medicine, Anqing Municipal Hospital, Anqing City, Anhui Provinces, China.
Rationale: Symmetrical peripheral gangrene (SPG) is a serious and rare complication in patients with urosepsis, characterized by distal limb symmetry impairment.
Patient Concerns: In this study, 3 cases of SPG caused by urosepsis were reported, and the Chinese and English literature on SPG caused by urosepsis was reviewed. The demographic, clinicopathological, treatment, and follow-up data of the patients were summarized and analyzed.
Is the phoenix sign phenomenon due to vasodilation? A double-blinded, randomized controlled trial comparing motor function recovery after diagnostic common fibular nerve block with lidocaine and papaverine.
BMC Musculoskelet Disord
October 2024
NE Wyoming Wound Care Clinic, Sheridan, WY, USA.
Article Synopsis
- Focal entrapment of the common fibular nerve (CFN) is a common issue in the lower body that can be hard to diagnose, with a temporary strengthening response known as the "Phoenix sign" sometimes observed after lidocaine blocks.
- A study involving 20 patients tested the effects of two vasodilating agents, lidocaine and papaverine, on improving muscle strength in the anterior compartment by measuring the extensor hallucis longus (EHL) muscle before and after treatment.
- Results showed that both agents produced significant improvements in muscle strength without notable differences between them, suggesting the Phoenix Effect is likely due to improved local blood circulation.
Effects of Papaverine on Experimentally Induced Myringosclerosis.
J Craniofac Surg
October 2024
Department of Medical Pathology, İzmir Faculty of Medicine, University of Health Sciences Turkey, İzmir, Türkiye.
Article Synopsis
- The study investigates how papaverine affects myringosclerosis (MS) in rats, focusing on its impact on hearing issues caused by the condition.
- Twenty Wistar albino rats were divided into four groups to test different treatments, including myringotomy, saline application, and both systemic and topical papaverine.
- Results indicated that papaverine increased the severity of MS, possibly due to its vasodilating effects that lead to higher levels of oxygen-derived free radicals, warranting further evaluation of its implications on MS.
The Effect of Local Papaverine Use in an Experimental High-Risk Colonic Anastomosis Model: Reduced Inflammatory Findings and Less Necrosis.
J Clin Med
September 2024
Department of Gastroenterology Surgery, Private Office, 06560 Ankara, Turkey.
To assess the impact of topical papaverine administration in complete and incomplete colonic anastomosis, by examining bursting pressure, hydroxyproline concentration, collagen content, inflammation levels, inflammatory cell infiltration, neoangiogenesis, and necrosis grades. We performed an experimental study on rats, in which they were divided into the following 4 groups of 16 subjects each. Group 1 [complete anastomosis (CA) without papaverine (CA -P) group], Group 2 [CA with papaverine (CA +P) group], Group 3 [incomplete anastomosis (ICA) without papaverine (ICA -P) group], and Group 4 [ICA with papaverine (ICA +P) group].
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