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Performance of the automated digital cell image analyzer UIMD PBIA in white blood cell classification: a comparative study with sysmex DI-60.
Clin Chem Lab Med
January 2025
Department of Laboratory Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.
Objectives: This study aimed to evaluate the performance of PBIA (UIMD, Seoul, Republic of Korea), an automated digital morphology analyzer using deep learning, for white blood cell (WBC) classification in peripheral blood smears and compare it with the widely used DI-60 (Sysmex, Kobe, Japan).
Methods: A total of 461 slides were analyzed using PBIA and DI-60. For each instrument, pre-classification performance was evaluated on the basis of post-classification results verified by users.
A Case of Leukemia Cutis (Acute Myeloid Leukemia) With Epidermotropism.
Am J Dermatopathol
February 2025
Department of Dermatology, Columbia University, New York, NY.
Acute myeloid leukemia is a cancer involving uncontrolled proliferation of hematopoietic cells. Cutaneous involvement is referred to as leukemia cutis (LC). The histopathologic presentation of LC is variable, and may present with perivascular, periadnexal, dermal, or subcutaneous infiltrate.
View Article and Find Full Text PDFExtracellular peroxiredoxin 5 exacerbates atherosclerosis via the TLR4/MyD88 pathway.
Atherosclerosis
January 2025
Heart-Immune-Brain Network Research Center, Department of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea; Imvastech Inc., 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea. Electronic address:
Backgroungd And Aims: Peroxiredoxin 5 (PRDX5), an atypical 2-Cys peroxiredoxin (PRDX), is known to regulate global oxidative stresses and inflammatory responses. Inflammation and oxidative stress are pivotal factors in the development of atherosclerosis, especially in the context of vascular endothelial dysfunction. However, effects of PRDX5 on atherosclerosis remain unclear.
View Article and Find Full Text PDFThe Impact of Pathologist Review on Peripheral Blood Smears: A College of American Pathologists Q-Probes Study of 22 Laboratories.
Arch Pathol Lab Med
November 2024
Essentia Health, St Mary's Medical Center, Duluth, Minnesota (Vos).
Context.—: The aim of the study was to determine the impact of peripheral blood (PB) smear review by a pathologist when requested by a technologist or provider to measure the rate of pathologist-detected clinically relevant findings.
Objective.
Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report.
J Med Case Rep
October 2024
Department of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1, Kohoku, Adachi-ku, 123-8558, Tokyo, Japan.
Article Synopsis
- Segregated-nucleus-containing atypical monocytes have been identified in mice and are believed to induce fibrosis in drug-injured lungs, with a human counterpart potentially existing in primary myelofibrosis.
- A 74-year-old male patient with primary myelofibrosis had anemia and elevated lactate dehydrogenase, and his bone marrow showed histological features consistent with the disease.
- Immunohistochemical analysis revealed the presence of some CD16MSR1CEACAM1 cells in the patient's bone marrow, suggesting a possible connection to murine atypical monocyte characteristics.
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