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CBX2 suppresses interferon signaling to diminish tumor immunogenicity via a noncanonical corepressor complex.
Proc Natl Acad Sci U S A
February 2025
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510050, China.
Chromobox 2 (CBX2), a crucial component of the polycomb repressive complex (PRC), has been implicated in the development of various human cancers. However, its role in the regulation of tumor immunogenicity and immune evasion remains inadequately understood. In this study, we found that ablation of CBX2 led to tumor growth inhibition, activation of the tumor immune microenvironment, and enhanced therapeutic efficacy of anti-PD1 or adoptive T cell therapies by using murine syngeneic tumor models.
View Article and Find Full Text PDFManagement of forgotten double J stents: insight from a systematic review of case reports.
Arch Ital Urol Androl
January 2025
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok.
Background: Double J Stent is one of the procedures frequently performed in the field of urology. Forgotten DJ Stent is a problem that can cause serious complications. This systematic review aims to explore complications and management of patients with forgotten double J stents.
View Article and Find Full Text PDFA comprehensive report of the clinical and mutational profiles of 30 Iranian malignant infantile osteopetrosis patients.
Mol Cell Probes
January 2025
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Osteopetrosis is a group of genetically and clinically diverse inherited disorders characterized by an increase in bone density. The main known cause is an abnormality in the development or function of osteoclasts. Hence, the process of bone resorption is impaired, resulting in: 1- a reduction in bone marrow volume and, subsequently, a decrement in the hematopoietic capacity of bone marrow, which leads to anemia and compromised immunological function; 2- improper bone development, which leads to pressure on peripheral nerves, causing auditory, visual, and movement impairments; and 3- disturbance in the formation of bone microstructure that leads to susceptibility to bone fracture.
View Article and Find Full Text PDFPrediction of surgical necessity in children with ureteropelvic junction obstruction using machine learning.
Ir J Med Sci
January 2025
Faculty of Medicine, Department of Pediatric Surgery Division of Pediatric Urology, Eskisehir Osmangazi University, Eskişehir, Turkey.
Background: Hydronephrosis developing at the ureteropelvic junction due to obstruction poses clinical challenges as it has the potential to cause renal damage.
Aims: This study aims to evaluate how well machine learning models such, as XGBClassifier and Logistic Regression can be used to predict the need for treatment in patients, with hydronephrosis resulting from ureteropelvic junction obstruction.
Methods: Hydronephrosis was diagnosed in the medical records of patients from January 2015 to December 2020.
Proteomic Profiling and Pre-Clinical Efficacy of Antimicrobial Lithium Complex and Colistin Combination against Multi-drug Resistant Acinetobacter baumannii.
Microb Pathog
January 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address:
Multi-drug resistant (MDR) Acinetobacter baumannii accounts for high mortality rates in hospital-acquired infections. Colistin is the last resort treatment despite nephrotoxic effects and the emergence of colistin resistant A. baumannii.
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