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Bipyramidal gold nanoparticles-assisted plasmonic photothermal therapy for ocular applications.
J Mater Chem B
January 2025
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, 14004 Cordoba, Spain.
Gold nanoparticles (AuNPs) play a key role in the field of nanomedicine due to their fascinating plasmonic properties as well as their great biocompatibility. An intriguing application is the use of plasmonic photothermal therapy (PPTT) mediated by anisotropic AuNPs irradiated with a near-infrared (NIR) laser for treating ocular diseases in ophthalmology. For this purpose, bipyramidal-shaped AuNPs (BipyAu), which were surface-functionalized with three different organic ligands (citrate, polystyrene sulphonate (PSS), and cetyltrimethylammonium bromide (CTAB)), were synthesized.
View Article and Find Full Text PDFUnveiling the conserved nature of chloroplast genomes: insights from the assembly and analysis of four complete chloroplast genomes.
Front Plant Sci
January 2025
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Introduction: , a genus within the Zingiberales order, is renowned for its diverse morphology, suggesting a rich genetic reservoir. However, genetic research on plants within the family has primarily focused on taxonomy and phylogenetics, with limited exploration into other genetic aspects, particularly the chloroplast genome. Given the significance of chloroplast genomes in evolutionary studies, a deeper understanding of their structure and diversity within Heliconia is essential.
View Article and Find Full Text PDFBackground: Previous studies have suggested that changes in the composition of the extracellular matrix (ECM) play a significant role in the development of ligamentum flavum hypertrophy (LFH) and the histological differences between the ventral and dorsal layers of the hypertrophied ligamentum flavum. Although LFH is associated with increased fibrosis in the dorsal layer, comprehensive research exploring the characteristics of the ECM and its mechanical properties in both regions is limited. Furthermore, the distribution of fibrosis-associated myofibroblasts within LFH remains poorly understood.
View Article and Find Full Text PDFSpatio-temporal variability of mesozooplankton distribution along the Canary Current Large Marine Ecosystem: a regional perspective.
J Plankton Res
January 2025
Institute of Marine Research (IMR), PO Box 1870, Nordnes, Bergen NO-5817, Norway.
The Canary Current Large Marine Ecosystem (CCLME), extending from Cape Spartel in Morocco to Guinea-Bissau, supports high primary and fisheries productivity driven by permanent or seasonal upwelling activity. During the current study, mesozooplankton and hydrographic sampling were conducted across the CCLME in the spring/summer of 2017 and the autumn/winter of 2019. The total mesozooplankton abundance and dry weight were found to be higher in 2017, partly due to the summer reproduction cycle of diplostracans.
View Article and Find Full Text PDFThe English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme.
BMJ Oncol
October 2023
Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Objective: In England, through the Genomic Medicine Service Alliances (GMSAs), a national transformation project aims to embed robust pathways to deliver universal Lynch syndrome (LS) testing for patients with colorectal and endometrial cancers. Prior to commencement of the project, there was evidence of variation and low testing levels in eligible patients which is consistent with other health systems; however, we believe this is amenable to systematic improvement with responsibility for testing delivery by local cancer teams supported by regional infrastructure.
Methods And Analysis: A project team and national oversight group was formed in May 2021 with membership including 21×cancer alliances, 7×GMSAs, charities and other stakeholders who agreed key performance indicators.
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