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Adaptation of clinical bacteriology techniques for remote polar research.
Appl Environ Microbiol
January 2025
Clinical Infection Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.
Unlabelled: Remote polar regions offer unique opportunities and significant challenges for antimicrobial resistance research in a near-pristine environment. While core microbiology techniques continue to have an important role in supporting environmental research, the severe cold climate presents considerable challenges to laboratory research. We explore adaptations required for core bacteriology investigations in polar regions on an unsupported remote expedition c.
View Article and Find Full Text PDFMorphometric analysis of extraocular muscles and proptosis by computed tomography in Graves' orbitopathy.
Radiol Bras
December 2024
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp), Botucatu, SP, Brazil.
Objective: To assess the prevalence of changes on computed tomography (CT) in Graves' orbitopathy (GO) and to correlate those changes with disease activity, as well as with clinical and biochemical variables.
Materials And Methods: This was a retrospective study, conducted at a tertiary hospital, of clinical, biochemical, and imaging data from consecutive patients with GO who underwent at least one orbital CT scan between July 2012 and December 2020. A single observer quantified the thickness of the extraocular muscles and the degree of proptosis.
Selection of Nonlethal Early Biomarkers to Predict Gilthead Seabream () Growth.
Aquac Nutr
January 2025
Department of Animal Science, Laboratory of Applied Hydrobiology, Agricultural University of Athens, Iera Odos 75 11855, Athens, Greece.
One of the main challenges in aquaculture is the constant search for sustainable alternative feed ingredients that can successfully replace fishmeal (FM) without any negative effects on fish growth and health. The goal of the present study was to develop a toolbox for rapidly anticipating the dynamics of fish growth following the introduction of a new feed; nonlethal, biochemical, and molecular markers that provide insights into physiological changes in the fish. A nutritional challenge by feeding a conventional feed rich in FM protein (FM diet) versus an experimental feed rich in plant protein (PP) and low FM inclusion (PP diet), in 20 different families of gilthead sea bream () was performed.
View Article and Find Full Text PDFFlavonoids of Diels et Gilg Against Acute Hepatic Injury by Blocking PI3K/AKT Signaling Pathway.
Mediators Inflamm
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
This study aims to investigate the mechanism of Diels et Gilg flavonoids (THF) on acute hepatic injury (AHI). First, high-performance liquid chromatography (HPLC) fingerprints were established to obtain the main chemical components of THF. According to the network pharmacology databases, collect active targets of AHI and potential targets.
View Article and Find Full Text PDFComparative Analysis of Biochemical and Lipid Profile Markers at Different Stages of Lung Cancer: A Cross-Sectional Study.
Cureus
December 2024
Biochemistry, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram, IND.
Background: Systemic inflammation, metabolic dysregulation, and changes in biochemical markers are closely associated with the progression of lung cancer. This study focuses on evaluating serum parathyroid hormone (PTH), C-reactive protein (CRP), lipid profile parameters, and interleukin-6 (IL-6) in relation to the stages of lung cancer, exploring their potential as biomarkers for assessing disease severity.
Methods: A total of 160 lung cancer patients were selected for a cross-sectional study and equally distributed into four clinical stages (Stages 1-4).
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