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Modulating Enzyme's Conformational Space: Impact of Substrate Binding, Mode Alteration, and Active Site Mutation in DapC, an Aminotransferase Enzyme of Lysine Biosynthetic Pathway.
J Phys Chem B
January 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
The microbial aminotransferase enzyme DapC is vital for lysine biosynthesis in various Gram-positive bacteria, including . Characterization of the enzyme's conformational dynamics and identifying the key residues for ligand binding are crucial for the development of effective antimicrobials. This study employs atomistic simulations to explore and categorize the dynamics of DapC in comparison to other classes of aminotransferase.
View Article and Find Full Text PDFImpact of antibiotics, iron oxide, and sodium sulfate on microbial community composition in laboratory-built municipal solid waste microcosms.
PLoS One
January 2025
Department of Earth and Environmental Sciences, University of Illinois at Chicago, Chicago, IL, United States of America.
Municipal solid waste (MSW) landfills represent underexplored microbial ecosystems. Landfills contain variable amounts of antibiotic and construction and demolition (C&D) wastes, which have the potential to alter microbial metabolism due to biocidal or redox active components, and these effects are largely underexplored. To circumvent the challenge of MSW heterogeneity, we conducted a 65-day time series study on simulated MSW microcosms to assess microbiome changes using 16S rRNA sequencing in response to 1) Fe(OH)3 and 2) Na2SO4 to represent redox active components of C&D waste as well as 3) antibiotics.
View Article and Find Full Text PDFInhibition of mitochondrial energy production leads to reorganization of the plant endomembrane system.
Plant Physiol
January 2025
State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China, P. R.
Mitochondria have generated the bulk of ATP to fuel cellular activities, including membrane trafficking, since the beginning of eukaryogenesis. How inhibition of mitochondrial energy production will affect the form and function of the endomembrane system and whether such changes are specific in today's cells remain unclear. Here, we treated Arabidopsis thaliana with antimycin A (AA), a potent inhibitor of the mitochondrial electron transport chain (mETC), as well as other mETC inhibitors and an uncoupler.
View Article and Find Full Text PDFA single-stage MABR reactor in the post-treatment of poultry slaughterhouse wastewater: nitrogen removal and microbial community.
Environ Technol
February 2025
PGEAGRI/CCET - Center of Exact Sciences and Technology, State University of Western of Paraná - UNIOESTE, Cascavel, Brazil.
The deammonification process is an efficient alternative to remove nitrogen from wastewater with a low carbon/nitrogen ratio. However, the reactor configuration and operational factors pose challenges for applications in treatment systems to remove nitrogen from municipal and industrial wastewater on a large scale. To address this gap, this study evaluated a new deammonification strategy using a single-stage membrane aerated biofilm reactor (MABR), operated with continuous flow, under different hydraulic retention times (HRT) in the post-treatment of poultry slaughterhouse wastewater with a low nitrogen load, similar to domestic wastewater.
View Article and Find Full Text PDFInoculum selection and hydraulic retention time impacts in a microbial fuel cell treating saline wastewater.
Appl Microbiol Biotechnol
January 2025
Environmental Microbiology Group, Institute of Water Research, University of Granada, 18003, Granada, Spain.
Microbial fuel cell (MFC) technology has received increased interest as a suitable approach for treating wastewater while producing electricity. However, there remains a lack of studies investigating the impact of inoculum type and hydraulic retention time (HRT) on the efficiency of MFCs in treating industrial saline wastewater. The effect of three different inocula (activated sludge from a fish-canning industry and two domestic wastewater treatment plants, WWTPs) on electrochemical and physicochemical parameters and the anodic microbiome of a two-chambered continuous-flow MFC was studied.
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