Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1749-6632.1965.tb56052.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer.
ACS Appl Mater Interfaces
January 2025
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT), Vall d'Hebron Institute of Research (VHIR), 08035 Barcelona, Spain.
Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with a very poor prognosis. It is characterized by a dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, the combination of CT with hyperthermia (HT) has been proposed as an innovative treatment modality for PDAC.
View Article and Find Full Text PDFPEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.
J Mater Chem B
January 2025
Biomedical Institute for Multimorbidity, Hull York Medical School, University of Hull, Hull, HU6 7RX, UK.
Article Synopsis
- Quantum dots (QDs) are small semiconductor particles that could improve biomedical imaging and drug delivery, with Indium phosphide QDs covered by zinc sulphide being a more biocompatible option.
- This study reveals that PEGylating these QDs significantly reduces platelet activation and aggregation, which is important to prevent excessive blood clotting.
- By decreasing the interaction between QDs and platelets, PEGylation enhances the safety and effectiveness of QDs for use in medical applications.
Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy.
ACS Mater Au
September 2024
Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France.
Multicore magnetic nanoparticles (MNPs), comprising iron oxide cores embedded in a sugar or starch matrix, are a class of nanomaterials with promising magnetic heating properties. Their internal structure, and particularly the strength of the internal core-core magnetic interactions, are believed to determine the functional properties, but there have been few detailed studies on this to date. We report here on an interlaboratory and multimodality transmission electron microscopy (TEM) and magnetic study of a high-performance MNP material (supplied by Resonant Circuits Limited, RCL) that is currently being used in a clinical study for the treatment of pancreatic cancer.
View Article and Find Full Text PDFProgress in nanoparticle-based electrochemical biosensors for hormone detection.
Nanoscale
October 2024
Department of Chemistry and Drug Technologies, Sapienza University of Rome, Rome, Italy.
Article Synopsis
- Hormones act as crucial chemical messengers controlling various bodily functions such as metabolism, growth, and mood, despite their low concentrations in the body.
- The review evaluates different nanoparticle-based electrochemical biosensors designed for detecting hormones like cortisol, estradiol, progesterone, testosterone, insulin, TSH, and GH, focusing on their detection methods and the biological fluids used.
- It discusses advancements in wearable biosensors and point-of-care testing for clinical diagnostics, including future integrations of nanomaterials and microfluidic technologies to enhance hormone detection capabilities.
Improved tumour delivery of iron oxide nanoparticles for magnetic hyperthermia therapy of melanoma ultrasound guidance and In SPECT quantification.
Nanoscale
October 2024
Healthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
Magnetic field hyperthermia relies on the intra-tumoural delivery of magnetic nanoparticles by interstitial injection, followed by their heating on exposure to a remotely-applied alternating magnetic field (AMF). This offers a potential sole or adjuvant route to treating drug-resistant tumours for which no alternatives are currently available. However, two challenges in nanoparticle delivery currently hinder the effective clinical translation of this technology: obtaining enough magnetic material within the tumour to enable sufficient heating; and doing this accurately to limit or avoid damage to surrounding healthy tissue.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!