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The impact of 3-sulfo-taurolithocholic acid on ATPase activity in patients' colorectal cancer and normal colon tissues, and its hepatic effects in rodents.
Front Vet Sci
December 2024
Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia.
Colorectal cancer is influenced by genetic mutations, lifestyle factors, and diet, particularly high fat intake, which raises bile acid levels in the intestinal lumen. This study hypothesized that bile acids contribute to tumorigenesis by disrupting ion transport and ATPase activity in the intestinal mucosa. The effects of 3-sulfo-taurolithocholic acid (TLC-S) on ATPase activity were investigated in colorectal cancer samples from 10 patients, using adjacent healthy tissue as controls, and in rodent liver function.
View Article and Find Full Text PDFImplications of the partial volume effect correction on the spatial quantification of hypoxia based on [F]FMISO PET/CT data.
Phys Med
December 2024
Division of Medical Physics, Department of Radiation Oncology, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site DKTK-Freiburg, Germany.
Article Synopsis
- This study analyzes how correcting the partial volume effect (PVE) in PET imaging improves the accuracy of measuring tumor hypoxia, specifically using FMISO PET images from head and neck cancer patients.
- The researchers found that PVE correction increased the calculated hypoxic tumor volume (HTV) and provided better alignment of oxygen pressure measurements with established data.
- They concluded that PVE correction is crucial for accurately quantifying tumor hypoxia, as it significantly impacts the assessment of treatment strategies and outcomes.
The impact of cannabinoid receptor 1 absence on mouse liver mitochondria homeostasis: insight into mitochondrial unfolded protein response.
Front Cell Dev Biol
October 2024
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Caserta, Italy.
Introduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
Analysis of stallion spermatozoa metabolism using Agilent Seahorse XFp Technology.
Anim Reprod Sci
December 2024
Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
Sperm metabolism consists of a sophisticated network of biochemical reactions and varies between species, resulting in different metabolic strategies for ATP production to maintain sperm functionality. ATP can be produced through glycolysis or in the mitochondria by oxidative phosphorylation (OXPHOS). Since OXPHOS is the predominant metabolic pathway in horses spermatozoa, various assessments of mitochondrial activity are used to evaluate fertility, utilizing techniques such as fluorescent probes analysed via microscopy or flow cytometry, and polarographic electrode assays to measure current flow in response to an applied voltage.
View Article and Find Full Text PDFMitochondrial Dysfunction Associated with mtDNA Mutation: Mitochondrial Genome Editing in Atherosclerosis Research.
Curr Med Chem
October 2024
Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia.
Article Synopsis
- * The study used a modified cell line containing the m.15059G>A mutation to assess the impacts of eliminating this mutation on mitochondrial function.
- * Results showed that removing the m.15059G>A mutation enhanced mitochondrial membrane potential and efficiency, reduced harmful byproducts, and did not alter the antioxidant system, indicating the mutation's negative role in mitochondrial health.
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