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A quantitative method for assessing treatment-related changes within the airway mucosa in patients with chronic bronchitis.
Respir Med
January 2025
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA, 19140, USA. Electronic address:
Background: No standardized method has yet been established for evaluating airway mucosal aberrancies associated with chronic obstructive pulmonary disease (COPD) or chronic bronchitis (CB). While goblet cell hyperplasia (GCH) is an established pathognomonic hallmark of the CB disease process, no standardized method exists for acquiring mucosal biopsies and assessing morphologic airway mucosa alterations. Additionally, the impacts from interventions targeting the airway mucosa are not well defined.
View Article and Find Full Text PDFWhole lung and sequential bronchoscopic lavage for pulmonary alveolar proteinosis.
Curr Opin Pulm Med
January 2025
Division of Respiratory and Critical Care Medicine, National University Hospital, Singapore.
Article Synopsis
- Pulmonary alveolar proteinosis (PAP) is a lung disease involving the buildup of lipoprotein material in alveoli due to surfactant issues, with whole lung lavage (WLL) being the main treatment since the 1960s.
- Autoimmune PAP, the most common type, results from antibodies affecting a crucial growth factor; however, there are currently no international treatment guidelines, and therapeutic strategies depend on PAP type and severity.
- Although WLL techniques have progressed, a standardized protocol is lacking, making careful planning and patient evaluation critical for successful treatment outcomes.
External Beam Radiotherapy for Malignant Central Airway Obstruction in a Remote Rural Patient: A Case Study.
Case Rep Oncol
November 2024
Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, SA, Australia.
Introduction: Malignant central airway obstruction (MCAO) is a challenging therapeutic scenario, caused by tumour burden which limits airflow within the large airways. Squamous cell carcinoma (SCC) of the lung accounts for 50% of MCAO seen in the setting of non-small cell lung cancer. Here, we present the challenging case of a 63-year-old Indigenous Australian Female rom a remote rural community with background history of metastatic SCC of presumed pulmonary origin, who presented with a 1-week history of dyspnoea, stridor, and hoarse voice.
View Article and Find Full Text PDFAnesthesia for Bronchoscopy-An Update.
J Clin Med
October 2024
Department of Anesthesiology and Perioperative Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
The field of interventional pulmonology has grown immensely and is increasingly recognized as a subspecialty. The new procedures introduced in the last decade pose unique challenges, and anesthesiologists need to readapt to their specific demands. In this review, we extensively discuss the pathophysiology, technical aspects, preprocedural preparation, anesthetic management, and postprocedural challenges of many new procedures such as navigational bronchoscopy, endobronchial valve deployment, and bronchial thermoplasty.
View Article and Find Full Text PDFTracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model.
Genes (Basel)
August 2024
The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, UK.
Article Synopsis
- Ovine pulmonary adenocarcinoma (OPA) is a serious lung disease in sheep that affects their health and costs farmers money.* -
- Scientists created a model to study OPA by giving sheep a virus called JSRV, and they found that different amounts of the virus led to various types of tumors.* -
- They used imaging techniques like CT scans and ultrasounds to monitor the tumors, discovering that these tools can effectively track the disease's progress, which helps improve research.*
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