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Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening.
Eur Radiol
January 2025
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Objective: To assess the co-occurrence of incidental CT lung findings (emphysema, bronchiectasis, and airway wall thickening) as well as associated risk factors in low-dose CT (LDCT) lung cancer screening in a Chinese urban population.
Methods: Data from 978 participants aged 40-74 years from the Chinese NELCIN-B3 urban population study who underwent LDCT screening were selected. CT scans were reviewed for incidental lung findings: emphysema, bronchiectasis and airway wall thickness.
A narrative review on allergy and exposure to domestic and non-domestic animals: favorable and unfavorable effects.
Eur Ann Allergy Clin Immunol
November 2024
Department of Experimental Medicine, Postgraduate School of Respiratory Medicine, University of Rome Tor Vergata, Rome, Italy.
The aim of this contribution was to highlight the "favorable" and "unfavorable" roles of domestic and non-domestic animals on airway sensitization processes and on the type/severity of the clinical symptoms induced by their exposure. We performed a literature research in MEDLINE for allergic manifestations and animals. Pets can be "allergy friends" through mechanisms related to hygiene hypothesis and translational aspects, the dual role of IgG4 antibodies for pets, and their promising role as healthcare service animals (dogs).
View Article and Find Full Text PDFBronchial thermoplasty for severe asthma: potential mechanisms and response markers.
Ther Adv Respir Dis
September 2024
National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No. 2, East Yinghua Road, Chaoyang District, Beijing 100029, China.
Article Synopsis
- Severe asthma (SA) is challenging to manage, significantly impacting patients' lives and straining healthcare resources.
- Bronchial thermoplasty (BT) is a promising non-drug treatment that has shown effectiveness in improving quality of life and reducing asthma attacks for over ten years.
- Despite its benefits, BT faces challenges in clinical use due to variability in patient responses and limited understanding of markers that can predict who will benefit from the treatment.
Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells.
Antioxidants (Basel)
July 2024
Projects and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, 431 83 Mölndal, Sweden.
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases.
View Article and Find Full Text PDFPiezo channels modulate human lung fibroblast function.
Am J Physiol Lung Cell Mol Physiol
October 2024
Department of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, United States.
Bronchial airways and lung parenchyma undergo both static and dynamic stretch in response to normal breathing as well as in the context of insults such as mechanical ventilation (MV) or in diseases such as asthma and chronic obstructive pulmonary disease (COPD) which lead to airway remodeling involving increased extracellular matrix (ECM) production. Here, the role of fibroblasts is critical, but the relationship between stretch- and fibroblast-induced ECM remodeling under these conditions is not well-explored. Piezo (PZ) channels play a role in mechanotransduction in many cell and organ systems, but their role in mechanical stretch-induced airway remodeling is not known.
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