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Minimising harms of tight glycaemic control in older patients with type 2 diabetes.
Afr J Prim Health Care Fam Med
December 2024
Department of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver.
In older adults with type 2 diabetes (T2DM), tight glycaemic control (HbA1c 7%) can result in more harm than benefit, especially when using insulin or sulfonylureas. Older adults are at higher risk for adverse drug events, especially hypoglycaemia, which may cause falls, confusion and hospitalisations. This Therapeutic Letter evaluates the risks of tight glycaemic control in older adults with T2DM, focusing on deprescribing diabetes medications in those over 65, especially those with multimorbidity and polypharmacy.
View Article and Find Full Text PDFNF-κB signaling is the major inflammatory pathway for inducing insulin resistance.
3 Biotech
February 2025
CSIR Institute of Genomics & Integrative Biology, Sukhdev Vihar, New Delhi, 110025 India.
Unlabelled: Insulin resistance is major factor in the development of metabolic syndrome and type 2 diabetes (T2D). We extracted 430 genes from literature associated with both insulin resistance and inflammation. The highly significant pathways were Toll-like receptor signaling, PI3K-Akt signaling, cytokine-cytokine receptor interaction, pathways in cancer, TNF signaling, and NF-kappa B signaling.
View Article and Find Full Text PDFBackground: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, mostly resulting from impaired insulin production and diminished glucose metabolism regulation. Qiwei Baizhu San (QWBZS) is a classic formula used in traditional Chinese medicine for the treatment of T2DM. A comprehensive analysis of the efficacy and safety of QWBZS in the treatment of T2DM is essential.
View Article and Find Full Text PDFEffect of Different Regional Characteristics of Spawning and Growing Sites on Growth and Taste of Pacific Oyster, .
Dev Reprod
December 2024
Department of Fisheries Biology, Pukyong National University, Busan 48513, Korea.
While Pacific oysters are important commercial aquaculture species worldwide, the effect of hormonal regulation and environmental conditions on growth and taste profile have not been fully known. Insulin-like growth factor (IGF) systems are known to play a major role in regulating neuroendocrine functions across various physiological processes and are particularly involved in growth. IGFs expression also is directly related to the nutritional status of vertebrates, however, full mechanism has not been clearly identified in bivalves.
View Article and Find Full Text PDFSteroid-induced diabetes in lupus nephritis patients: Classic risk factors or a different type of diabetes?
Lupus
January 2025
Department of Medical Education, INCMNSZ, Ciudad de Mexico, Mexico.
Background: Glucocorticoids are frequently employed in systemic lupus erythematosus (SLE) patients and play a critical role in the induction therapy of lupus nephritis (LN), despite their many side effects, including steroid-induced diabetes (SID). Information regarding SID in SLE patients is quite scant.
Purpose: The aim of this study was to determine risk factors associated with the development of SID in patients with LN.
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