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Posterior reversible encephalopathy syndrome (PRES) is a reversible clinico-radiological condition primarily affecting the occipito-parietal regions. Thalami, brainstem, and cerebellar involvement with posterior fossa oedema are rare manifestations of this condition. We present the case of a 66-year-old male with a travel history to Thailand who was found collapsed on the floor two weeks after his return.
View Article and Find Full Text PDFA clinico-radiological review of chronic non-bacterial osteomyelitis in paediatrics, adolescents, and adults: demystifying a forgotten differential.
Clin Radiol
March 2024
Faculty of Medicine, The University of British Columbia, 317 - 2194 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada; Department of Radiology, Vancouver General Hospital, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada.
Chronic non-bacterial osteomyelitis (CNO), also known as non-bacterial osteitis, is a chronic autoinflammatory disease of unknown aetiology that primarily occurs in the paediatric population, although rare cases of adult-onset disease also exist. CNO has non-specific clinical and radiological presentations, and the affected population often present with bone pain of insidious onset secondary to sterile bony inflammation that can be associated with swelling, focal tenderness, and warmth at the affected sites. The pattern of bony involvement appears to be dependent on the age of onset, with adults frequently having axial skeletal lesions and children and adolescents often being affected in the appendicular skeletal sites.
View Article and Find Full Text PDFHypertrophic pachymeningitis due to IgG4-related disease (RD-IgG4). A case report.
Reumatol Clin (Engl Ed)
June 2023
Servicio de Diagnóstico por Imágenes, Hospital José María Cullen, Santa Fe, Argentina.
Introduction: Hypertrophic pachymeningitis (HP) is a clinico-radiological entity characterized by a thickening of the dura mater that may be focal or diffuse and manifested by a variety of neurological syndromes. Aetiologically, it is classified as infectious, neoplastic, autoimmune, and idiopathic. Many of these formerly idiopathic cases have been shown to fall into the spectrum of IgG4-related disease.
View Article and Find Full Text PDFProgressive Flaccid Paraplegia in a Toddler due to Chiari Type I Malformation Complicated with Hydrocephalus and Syringomyelia. A Case Report.
Child Neurol Open
April 2023
Department of Child Neurology, Children's Hospital Orange County, Orange, CA, USA.
Chiari malformation is a clinico-radiological entity defined by herniation of rhombencephalic structures through the foramen magnum. The most common type, Chiari I, involves herniation of the cerebellar tonsils specifically. We present the case of a 2-year-old with three weeks of progressive bilateral leg weakness, absent reflexes, and the inability to walk.
View Article and Find Full Text PDFDeciphering the clinico-radiological heterogeneity of dysexecutive Alzheimer's disease.
Cereb Cortex
May 2023
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Article Synopsis
- Dysexecutive Alzheimer's disease (dAD) is a condition that leads to executive function decline without major behavioral changes, showing significant variation in patient presentations.
- In a study of 52 dAD patients, machine learning revealed six factors of brain metabolism, leading to the identification of four dAD subtypes based on neuroimaging data: "left-dominant," "right-dominant," "bi-parietal-dominant," and "heteromodal-diffuse."
- These dAD subtypes showed differences in clinical severity and age of onset, with the "heteromodal-diffuse" subtype experiencing worse symptoms, while the "bi-parietal" subtype presented milder symptoms, indicating the need
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