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Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.
BMC Res Notes
March 2025
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.
Results: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included.
Apigenin improves chronic gastric ulcer in rats: The implication of COX-1/2 and 5-LOX signaling pathways.
Tissue Cell
March 2025
Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; Department of Anatomy, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain. Electronic address:
Peptic ulcer is a prevalent gastrointestinal illness. The aim is to investigate the possible implication of cyclooxygenase (COX)-1/2 and 5-lipoxygenase (5-LOX) signaling pathways in apigenin therapeutic effect on acetic acid-induced chronic gastric ulcer maintained with indomethacin. Rats were divided into 5 groups (n = 10): control, ulcer, omeprazole+ulcer, apigenin+ulcer, and apigenin only groups.
View Article and Find Full Text PDFGastrointestinal traits, common inflammatory disorders, gallstones, and biliary tract cancer: A network Mendelian randomization study.
J Adv Res
March 2025
Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address:
Introduction: Observational studies have shown that gallstone disease (GSD), cholecystitis, cholangitis, polyp of gallbladder, viral hepatitis, pancreatitis and gastrointestinal (GI) traits such as H. pylori infection, inflammatory bowel disease, and digestive ulcer are associated with the risk of biliary tract cancer (BTC). However, no study has explored their causal associations.
View Article and Find Full Text PDFMind the gut: Navigating the complex landscape of gastroprotection in neurosurgical patients.
World J Gastroenterol
February 2025
Department of Neurosurgery, University of Flordia, Gainesville, FL 32608, United States.
Neurosurgical patients, including those with severe traumatic brain injury, spinal cord injury, stroke, or raised intracranial pressure, are at heightened risk for stress ulcers and aspiration pneumonitis, leading to significant morbidity and mortality. These patients are typically managed through both pharmacological interventions [, proton pump inhibitors (PPIs), histamine 2 (H2) antagonists, sucralfate] and non-pharmacological measures (, nasogastric decompression, patient positioning) to mitigate adverse outcomes. The pathogenesis of stress ulcers in neurosurgical patients is multifactorial, but the routine use of stress ulcer prophylaxis remains controversial.
View Article and Find Full Text PDFRetrospective comparative study of different surgical methods for gastric ulcer perforation: Efficacy and postoperative complications.
World J Gastrointest Surg
February 2025
Department of Thyroid Surgery, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Background: Gastric ulcer perforation is a critical condition that can lead to significant morbidity and mortality if not promptly addressed. It is often the result of chronic peptic ulcer disease, which is characterized by a breach in the gastric wall due to ulceration. Surgical intervention is essential for managing this life-threatening complication.
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