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Ferroptosis- and stemness inhibition-mediated therapeutic potency of ferrous oxide nanoparticles-diethyldithiocarbamate using a co-spheroid 3D model of pancreatic cancer.
J Gastroenterol
January 2025
Division of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham (UAB), Birmingham, Alabama, 35294, USA.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high mortality rate and exhibits a limited response to apoptosis-dependent chemotherapeutic drugs (e.g., gemcitabine, Gem).
View Article and Find Full Text PDFSolution-Gated Thin Film Transistor Biosensor-Based SnO Amorphous Film for Label-Free Detection of Epithelial Cell Adhesion Molecules.
ACS Sens
January 2025
Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.
Epithelial cell adhesion molecule (EpCAM) was considered to be an important marker of multiple tumors, and its high expression is closely related to the early diagnosis and treatment of tumors. At present, metal oxide semiconductors have become a key component of biosensor and bioelectronics technology. Tin oxide shows great potential for development because of its nontoxic, nonpolluting, low price, and excellent electrical properties.
View Article and Find Full Text PDFInvestigating the effects of a high boiling point solvent in slot die-coated halide perovskite solar cells.
ChemSusChem
January 2025
Nanyang Technological University - Jurong Campus: Nanyang Technological University, School of Materials Science and Engineering, Block N4.1, 50 Nanyang Avenue, 639798, Singapore, SINGAPORE.
To commercialize perovskite solar cells and advance beyond lab-scale comparisons, understanding large-area film formation using slot-die coating is essential to improve film homogeneity. Adding high-boiling-point solvents like NMP to the perovskite ink extends film's processing window, but the effects of varying NMP levels on gas-quenched slot-die coatings remain unclear. This article examines how different NMP ratios impact film quality, showing that a moderate amount of NMP as a co-solvent reduces defects, as observed through photoluminescence, hyperspectral absorbance, and back-illuminated optical absorptions.
View Article and Find Full Text PDFSelf-Adaptive Polarized Photoresponse in Organic Single-Crystal Phototransistors for Bionic Night-Time Polarization Perception.
Adv Mater
January 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
The emerging semiconductor micro/nanocrystals with intrinsic anisotropy have provided new perspectives for low-cost and simplified polarimetry. However, the low polarization sensitivity of state-of-the-art polarimeters based on anisotropic semiconductors under weak and partially polarized light severely hinders their practical application in complex dim environments. Here, a photo-adaptive polarization-sensitive organic phototransistor (POL-OPT) is demonstrated for bionic weak-light polarization perception.
View Article and Find Full Text PDFForsythiaside A Ameliorates Inflammation by Regulating the Autophagy in Methotrexate-induced Intestinal Mucositis.
Comb Chem High Throughput Screen
January 2025
Hebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Background: Methotrexate (MTX) effectively eliminates cancerous cells but can also cause inflammation intestinal, known as mucositis. Forsythiaside A (FTA) from Forsythia suspensa has shown promise in relieving mucositis by targeting the NLRP3 pathways. Since NLRP3 inflammasome activation is negatively regulated by autophagy, this study explores how FTAmediated autophagy affects NLRP3 inflammasome in treating MTX-induced intestinal inflammation.
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