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Intraoperative tranexamic acid reduces postoperative haemarthrosis and improves early functional outcomes in double-bundle anterior cruciate ligament reconstruction.
J Orthop
July 2025
The Department of Orthopedics Surgery, Ningbo No. 6 Hospital, Ningbo, China, 315040, 1059# ZhongShan East Road, Ningbo, Zhejiang, People's Republic of China.
Introduction: Double-bundle anterior cruciate ligament reconstruction (ACLR) has biomechanical advantages but is associated with increased intraoperative bleeding. The role of tranexamic acid (TXA) in reducing postoperative joint haemarthrosis and improving the short-term outcomes of double-bundle ACLR has not yet been thoroughly investigated. This study aimed to assess the effects of intraoperative TXA on postoperative joint haemarthrosis and short-term functional outcomes in patients who underwent double-bundle ACLR.
View Article and Find Full Text PDFComprehensive Analysis of Minimally Invasive Management for Persistent Anterolateral Ankle Pain: A Systematic Review.
Cureus
December 2024
Trauma and Orthopaedics, Royal Devon and Exeter University Hospital, Devon, GBR.
Persistent anterolateral ankle pain is a debilitating condition often associated with soft tissue impingement following inversion injuries. It can lead to significant limitations in daily activities and overall quality of life, particularly in individuals with chronic ankle instability. This systematic review examines the efficacy and safety of minimally invasive arthroscopic decompression techniques in managing anterolateral ankle impingement syndrome.
View Article and Find Full Text PDFPain-Related Quality of Life Outcomes in People With Haemophilia A Receiving Emicizumab: A Post Hoc Analysis of the HAVEN 1, 3 and 4 and STASEY Studies.
Haemophilia
December 2024
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Introduction: People with haemophilia A (PwHA) experience acute and chronic pain associated with reduced quality of life (QoL).
Aims: This post hoc analysis of pooled data from the HAVEN 1 (NCT02622321), 3 (NCT02847637), 4 (NCT03020160) and STASEY (NCT0319179) studies assessed the impact of emicizumab prophylaxis on pain-related QoL in PwHA.
Methods: PwHA received emicizumab during the four studies.
Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis.
Appl Sci (Basel)
July 2024
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Recurrent bleeding in the synovial joint, such as the knee, can give rise to chronic synovitis and degenerative arthritis, which are major causes of morbidity. Whereas chronic arthropathy affects one-fifth of hemophiliacs, conditions such as rheumatoid arthritis (RA), periarticular and articular fractures, osteochondral autograft transplantation surgery, and anterior cruciate ligament (ACL) injury are also associated with joint bleeding. Synovial joint trauma is associated with inflammation, acute pain, bloody joint effusion, and knee instability.
View Article and Find Full Text PDFEarly Outcome of a Contemporary Unicondylar Knee System.
Cureus
November 2024
Orthopaedics, Anderson Orthopaedic Clinic, Arlington, USA.
Introduction: In 2019, a new fixed-bearing implant for unicondylar knee arthroplasty (UKA) was introduced that incorporated a round-on-flat design featuring an Oxinium femoral component coupled with a highly crosslinked polyethylene bearing surface. Compared to prior implants, the design featured smaller size increments coupled with medial and lateral-specific tibial baseplates. The objective of this study is to describe our institution's early experience with this UKA implant system by evaluating survivorship, reasons for revision, and patient-reported outcome measures (PROMs).
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