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Substitution load revisited: a high proportion of deaths can be selective.
Genetics
January 2025
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA.
Haldane's Dilemma refers to the concern that the need for many "selective deaths" to complete a substitution (i.e. selective sweep) creates a speed limit to adaptation.
View Article and Find Full Text PDFCross- analyzing the opinions and experiences of nurses, physiotherapists, dentists, midwives, and pharmacists with respect to addictive disorder screening in primary care: A qualitative study.
PLoS One
January 2025
Department of General Practice, Tours Regional University Hospital, Tours, France.
Early addiction disorders screening is recommended in primary care. The goal of health system reform is to include allied health professionals in this screening. The appropriation of their new role has not yet been explored.
View Article and Find Full Text PDFTaking the Next Step in Neurologic Rehabilitation: Contributions of Intensity and Variability of Stepping Tasks during Locomotor Training.
Phys Ther
January 2025
Department of Physical Medicine and Rehabilitation.
Research over the past 20 years indicates the amount of task-specific walking practice provided to individuals with stroke, brain injury, or incomplete spinal cord injury can strongly influence walking recovery. However, more recent data suggest that attention towards 2 other training parameters, including the intensity and variability of walking practice, may maximize walking recovery and facilitate gains in non-walking outcomes. The combination of these training parameters represents a stark contrast from traditional strategies, and confusion regarding the potential benefits and perceived risks may limit their implementation in clinical practice.
View Article and Find Full Text PDFNonconvulsive status epilepticus in patients under intensive care: Should we view epilepsy as a sleep disorder?
Epilepsia
January 2025
Epilepsy Unit, Gui de Chauliac Hospital, Montpellier, France.
Nonconvulsive status epilepticus (NCSE) was initially described in patients with typical and atypical absence status epilepticus (ASE) characterized by states of confusion varying in severity and in focal epilepsies with or without alteration of consciousness. Continuous EEG monitoring of critically ill patients has further refined the classification of NCSE into two main categories: with coma and without coma. Hypnotic, soporific or somniferous epileptic seizures do not exist.
View Article and Find Full Text PDFExploring the use and usefulness of living guidelines for consumers: international online survey of patients' and carers' views.
J Clin Epidemiol
January 2025
Australian Living Evidence Collaboration, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: Living guidelines contain continually updated, and potentially changing, clinical recommendations. The implications of living guidelines for consumers (e.g.
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