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Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA.
Mol Ther Nucleic Acids
March 2025
Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance vascular permeability and gene penetration. Here, we explore the influence of flow rate on the microbubble-assisted delivery of miR-126, a potent pro-angiogenic biologic, using a custom acoustically coupled pressurized mesenteric artery model.
View Article and Find Full Text PDFEffects of salt stress on plant and rhizosphere bacterial communities, interaction patterns, and functions.
Front Plant Sci
January 2025
Key Laboratory of Innovation of Forage Efficient Production Model, Ministry of Agriculture and Rural Affairs, Yinchuan, Ningxia Hui Autonomous Region, China.
Introduction: Salt stress significantly affects plant growth, and Na has gained attention for its potential to enhance plant adaptability to saline conditions. However, the interactions between Na, plants, and rhizosphere bacterial communities remain unclear, hindering a deeper understanding of how Na contributes to plant resilience under salt stress.
Methods: This study aimed to investigate the mechanisms through which Na promotes alfalfa's adaptation to salt stress by modifying rhizosphere bacterial communities.
Screening and identification of two novel phosphate-solubilizing strains and their role in enhancing phosphorus uptake in rice.
Front Microbiol
January 2025
Rice Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of New Technology in Rice Breeding/Guangdong Rice Engineering Laboratory/Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Guangzhou, China.
Low phosphorus (P) use efficiency significantly impacts rice yields. An environmentally friendly approach to increase phosphorus absorption and utilization in rice involves the exploration of phosphorus-solubilizing fungal resources. This study aimed to isolate and characterize fungal strains from the rice rhizosphere and assess their phosphate solubilization capabilities, plant-growth-promoting (PGP) traits, and mechanisms involved.
View Article and Find Full Text PDFDietary supplements for prevention of Alzheimer's disease: and molecular docking studies.
Iran J Basic Med Sci
January 2025
Nutrition and Food Science Department, Food Industries and Nutrition Institute, National Research Centre, Dokki 12622, Cairo, Egypt.
Objectives: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in people over 65. The present research aimed to investigate the potential of different dietary supplements (DS) in preventing AD in an experimental animal model and study.
Materials And Methods: Three DS containing a mixture of wheat-germ oil and black pepper extract/or turmeric extract were prepared.
Maillard reaction inducing amino acids degradation can adjust the flavour characteristic of black tea.
Food Res Int
February 2025
Tea Research Institute, China Academy of Agricultural Sciences, Key Laboratory of Tea Biology and Resource Utilization, Ministry of Agriculture, Hangzhou 310008, China. Electronic address:
Drying is the step that is to be used to adjust and control the formation of flavour and quality in black tea processing. In the present work, the comprehensive two-dimensional gas chromatography with mass spectrometry (GC × GC-MS) and gas chromatography olfactometry with mass (GC-O-MS) were used to determine the dynamic change of the volatile compounds in black tea during drying at 90, 120, 150 °C for 1 h. Results showed that the ratio of esters and aldehydes largely declined when temperature was elevated from 90 °C to 150 °C, while the ratio of heterocycles was increased to 22.
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