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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing.
J Pharm Anal
December 2024
MTA-HUN-REN TTK Lendület "Momentum" Peptide-Based Vaccines Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, H-1117, Hungary.
The aim of the research is to increase the applicability of lipopeptides as drugs. To this end, non-ionic triblock copolymers, namely poloxamers, were applied. The physico-chemical properties of poloxamers vary depending on the length of the blocks.
View Article and Find Full Text PDFImplementation of a clinical pathway for diabetes-related foot ulcers reduced the number of amputations and shortened hospital stay.
J Foot Ankle Res
March 2025
Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog, Norway.
Introduction: Diabetes-related foot ulcer (DFU) is the leading cause for lower extremity amputations (LEAs) in western countries, and may cause social isolation, depression, and death. However, people with DFU are not offered the same prioritized care as cancer patients, despite comparable mortality rates. We therefore decided to create a clinical pathway for patients with DFU.
View Article and Find Full Text PDFEnhancement of Oryzanol application by constructing modified β-CD inclusion complex and polycaprolactone-chitosan electrospun fiber membranes: Perspectives on wound dressings and grape preservation.
Food Chem
January 2025
National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.
Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate Oryzanol.
View Article and Find Full Text PDFWounds from gunshots and other explosive devices are a source of loss of substances directly or secondary to a well- conducted debridement. In addition, these types of wounds are by definition contaminated. The major challenge in this context for any surgeon remains coverage.
View Article and Find Full Text PDFThe Role of Value Analysis in Pressure Injury Prevention: A Quality Improvement Project.
J Wound Ostomy Continence Nurs
January 2025
Stephanie Constable, BSN, RN, CWOCN, Wound Care and Ostomy, United Hospital Center, Bridgeport, West Virginia.
Purpose: Global pressure injury (PI) statistics reveal that hospital-acquired pressure injuries (HAPIs) remain a substantial burden, with over 1 in 10 hospitalized adults being affected. The purpose of this analysis is to describe how consistent collection, analysis, and use of data allow hospitals to validate their clinical and economic outcomes and to adjust PI prevention strategies.
Participants And Setting: HAPI incidence data for acute care patients at a 280-bed regional community hospital in the Mid-Atlantic region of the United States (West Virginia) were collected from January 2012 to July 2023.
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