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Contrast-enhanced CT Lymphangiography for Various Central Lymphatic Disorders.
Radiographics
December 2024
From the Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.
Lymphatic leakage, manifesting as chylothorax or chylous ascites, arises from traumatic or nontraumatic causes and poses severe risks such as malnutrition and increased infection susceptibility. Accurate diagnosis and an effective treatment strategy necessitate comprehensive lymphatic imaging. Conventional lymphangiography and dynamic contrast-enhanced MR lymphangiography (DCMRL) have been widely used and studied as effective lymphatic imaging methods.
View Article and Find Full Text PDF[Staged operations of acquired lymphangiectasia of the vulva: 10 cases clinical analysis].
Zhonghua Fu Chan Ke Za Zhi
October 2024
Department of Lymph Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, China.
Article Synopsis
- This study examined acquired lymphangiectasia of the vulva (ALV) by retrospectively analyzing clinical data from patients treated at a hospital over 14 years, focusing on their characteristics, diagnosis, and treatment outcomes.* -
- Out of 48 patients with ALV, 10 underwent staged surgical operations, including labiectomy and lymphatic procedures, with evaluations conducted to track improvements in symptoms like swelling and fluid leakage.* -
- The findings indicated a median age of 60 years among patients, most having a history of pelvic malignancies and radiotherapy, with common symptoms like blisters and lymphatic obstruction observed through imaging studies.*
MR Lymphangiography: Congenital Lymphatic Flow Disorders.
Invest Radiol
January 2025
From the Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea (S.L., S.H., Y.H.C., J.-Y.H., J.-E.C.); Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea (S.L., S.H., Y.H.C., J.-Y.H., J.-E.C.); and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea (J.-E.C.).
Congenital lymphatic flow disorders collectively refer to a heterogeneous group of diseases that manifest as chylothorax, chylous ascites, intestinal lymphangiectasia, protein-losing enteropathy, and peripheral extremity or genital lymphedema, all in the absence of identifiable injury to the lymphatic system. We have only recently begun to understand congenital lymphatic flow disorders through the ability to image lymph flow dynamically. Intranodal dynamic contrast-enhanced magnetic resonance lymphangiography (DCMRL) is a crucial technique for imaging lymphatic flow in pediatric patients with congenital lymphatic flow disorders.
View Article and Find Full Text PDFAnalysis on efficacy of magnetic resonance lymphangiography using INV-001 in healthy beagle dogs.
Sci Rep
May 2024
Departments of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, Olymphic-ro 43 Gil 88, Songpa-gu, Seoul, 138-735, Republic of Korea.
Article Synopsis
- The study focused on testing INV-001 for visualizing lymphatic vessels and nodes in beagles using magnetic resonance lymphangiography (MRL) without impacting venous systems.
- An adaptive dose-finding study was performed on six beagles, determining that the optimal dose for clear visualization was 0.056 mg Fe/kg at a concentration of 15 mM, showing effective enhancement within 30 minutes of administration.
- No toxicity was observed, and analysis of liver and kidney T, T, and T* values 48 hours later indicated complete excretion of INV-001, confirming its safety and effectiveness for the intended application.
Surgical Treatment of Breast Lymphedema: A Distinct Pathology With Unique Challenges.
Ann Plast Surg
May 2024
Division of Plastic and Reconstructive Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Supermicrosurgical advances such as lymphovenous bypass (LVB) have enabled effective physiologic treatment of lymphedema affecting the extremities. Reports of surgical treatment for breast lymphedema (BL) are sparse, consisting of case reports and almost exclusively LVB. We report our experience with BL, including a case of mastectomy and breast reconstruction with abdominal free flap and inguinal vascularized lymph node transfer (VLNT) for BL.
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