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Early case series with placement of NeuroOne Evo stereoelectroencephalography depth electrodes and review of other Food and Drug Administration-approved products.
Surg Neurol Int
December 2024
Department of Neurosurgery, University of California, Irvine, Orange, United States.
Background: Stereoelectroencephalography (SEEG) is a common diagnostic surgical procedure for patients with medically refractory epilepsy. We aimed to describe our initial experience with the recently released NeuroOne Evo SEEG electrode product (Zimmer Biomet, Warsaw, IN) and review technical specifications for other currently approved depth SEEG electrodes.
Methods: We performed a record review on the first five patients implanted with NeuroOne Evo SEEG electrode product using the robotic stereotactic assistance robot platform and described our surgical technique in detail.
Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice.
Front Pharmacol
November 2024
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Background: Stress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression, oxidative stress, increased levels of neuroinflammatory cytokines, and increased expression of apoptotic genes contribute to the underlying cause of the seizure.
View Article and Find Full Text PDFDissecting the association between blood pressure traits, hypertension, antihypertensive medications and epilepsy: A Mendelian randomization study.
Epilepsy Behav
December 2024
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: Observational studies suggest that hypertension and epilepsy have a high co-occurrence, and antihypertensive medications may have impacts on the prevention and treatment of epilepsy. However, the directionality of causation between them is elusive.
Method: By leveraging genome-wide association studies (GWAS) summary data of each trait, we firstly performed bidirectional univariate Mendelian randomization (UVMR) to assess the strength and direction of the associations between pairs of traits, then multivariate MR (MVMR) was conducted to adjust for potential confounders in causalities.
Is lateralization concordance between preoperative video-EEG, ictal SPECT, and MRI to be associated with positive psychiatric outcomes after cortico-amygdalohippocampectomy in patients with pharmacoresistant temporal lobe epilepsy associated to mesial temporal sclerosis? A retrospective cohort study.
Epilepsy Behav
December 2024
Department of Neurological Sciences, Psychiatry, and Medical Psychology, Faculdade de Medicina de São Jose do Rio Preto (FAMERP), São Paulo, Brazil.
Article Synopsis
- The study investigates the relationship between comorbid psychiatric disorders and pharmacoresistant temporal lobe epilepsy (TLE) associated with mesial temporal sclerosis (MTS), focusing on pre-surgical factors that could influence post-surgical psychiatric outcomes.
- A retrospective analysis was conducted on 106 patients, with 51 having psychiatric disorders (PD) and 55 without, to identify predictors for post-surgical PD two years after cortico-amygdalohippocampectomy (CAH).
- Results indicated that previous psychiatric treatment was linked to the development of PD post-surgery, with 35% of patients experiencing remission of PD and 14.5% developing new PD after CAH, underscoring the complexity of
Characterizing Depth Electrode Coverage in Stereoelectroencephalography on Seizure Onset Zone Localization and Seizure Outcomes.
Stereotact Funct Neurosurg
December 2024
Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- * It finds that while more implanted contacts may increase the chances of treatment progression, they do not correlate with better SOZ localization or improved seizure outcomes, with specific brain regions more frequently linked to seizure onset.
- * Overall, SEEG is effective for localizing SOZ in various types of epilepsy, helping guide treatment decisions despite variability in electrode placement across institutions.
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