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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome.
J Neurodev Disord
January 2025
Rett Syndrome Research Trust, Trumbull, CT, USA.
Background: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy.
Design: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy.
Methods: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite treatment.
Early case series with placement of NeuroOne Evo stereoelectroencephalography depth electrodes and review of other Food and Drug Administration-approved products.
Surg Neurol Int
December 2024
Department of Neurosurgery, University of California, Irvine, Orange, United States.
Background: Stereoelectroencephalography (SEEG) is a common diagnostic surgical procedure for patients with medically refractory epilepsy. We aimed to describe our initial experience with the recently released NeuroOne Evo SEEG electrode product (Zimmer Biomet, Warsaw, IN) and review technical specifications for other currently approved depth SEEG electrodes.
Methods: We performed a record review on the first five patients implanted with NeuroOne Evo SEEG electrode product using the robotic stereotactic assistance robot platform and described our surgical technique in detail.
Antidepressant response time across intermittent theta burst stimulation regimens and efficacy indicators in adolescents depression: a secondary analysis from a randomized controlled trial.
BMC Psychiatry
December 2024
The Affiliated Brain Hospital, Guangzhou Medical University, Liwan District, No. 36, Mingxin Road, Guangzhou, Guangdong, China.
Background: Accelerated intermittent theta burst stimulation (aiTBS), which involves the administration of multiple daily sessions of iTBS, represents a novel regimen of repetitive transcranial magnetic stimulation. Studies have suggested that aiTBS may facilitate a fast response among patients with major depressive disorders. However, whether aiTBS can accelerate antidepressant response in adolescents suffering from depression is still unclear.
View Article and Find Full Text PDFIs lateralization concordance between preoperative video-EEG, ictal SPECT, and MRI to be associated with positive psychiatric outcomes after cortico-amygdalohippocampectomy in patients with pharmacoresistant temporal lobe epilepsy associated to mesial temporal sclerosis? A retrospective cohort study.
Epilepsy Behav
December 2024
Department of Neurological Sciences, Psychiatry, and Medical Psychology, Faculdade de Medicina de São Jose do Rio Preto (FAMERP), São Paulo, Brazil.
Article Synopsis
- The study investigates the relationship between comorbid psychiatric disorders and pharmacoresistant temporal lobe epilepsy (TLE) associated with mesial temporal sclerosis (MTS), focusing on pre-surgical factors that could influence post-surgical psychiatric outcomes.
- A retrospective analysis was conducted on 106 patients, with 51 having psychiatric disorders (PD) and 55 without, to identify predictors for post-surgical PD two years after cortico-amygdalohippocampectomy (CAH).
- Results indicated that previous psychiatric treatment was linked to the development of PD post-surgery, with 35% of patients experiencing remission of PD and 14.5% developing new PD after CAH, underscoring the complexity of
Characterizing Depth Electrode Coverage in Stereoelectroencephalography on Seizure Onset Zone Localization and Seizure Outcomes.
Stereotact Funct Neurosurg
December 2024
Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- * It finds that while more implanted contacts may increase the chances of treatment progression, they do not correlate with better SOZ localization or improved seizure outcomes, with specific brain regions more frequently linked to seizure onset.
- * Overall, SEEG is effective for localizing SOZ in various types of epilepsy, helping guide treatment decisions despite variability in electrode placement across institutions.
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