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P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways.
J Ethnopharmacol
January 2025
Department of Pharmacology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 561113, China; Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 561113, China; Guizhou Provincial Engineering Technology Research Center for Chemical Drug RandD, Guizhou Medical University, Guiyang, 561113, China. Electronic address:
Ethnopharmacological Relevance: Cryptotanshinone serves as the principal bioactive constituent of Salvia miltiorrhiza Bunge, possesses a wide range of pharmacological activities. Salvia miltiorrhiza Bunge, a long-standing therapeutic agent in traditional Chinese medicine (TCM) practice, is renowned for its efficacy in enhancing blood circulation and alleviating blood stasis and infarction, thereby treating cardiovascular and cerebrovascular diseases.
Aim Of The Study: Platelet activation, when excessive or aberrant, poses a significant risk, catalyzing the onset of various thrombotic disorders.
Title: Is Celiac Trunk Revascularization Necessary After High-Flow Pancreaticoduodenal Arterial Arcades Aneurysm Retrograde Embolization?
J Clin Med
November 2024
Medical Imaging Department, Henri Mondor University Hospital Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
High-flow pancreaticoduodenal artery (PDA) aneurysms secondary to celiac trunk occlusion or stenosis have a high risk of rupture. Embolization offers a less invasive alternative to surgery. We evaluated the effectiveness and safety of retrograde embolization via the superior mesenteric artery of high-flow PDA aneurysms without celiac trunk revascularization.
View Article and Find Full Text PDFImpact of direct mesenteric perfusion on malperfusion in acute type A aortic dissection repair.
Eur J Cardiothorac Surg
December 2024
Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Objectives: Mesenteric malperfusion in acute aortic dissection remains a life-threatening complication with no standardized treatment strategy. This study aimed to describe and evaluate the outcomes of our integrated approach combining exploratory laparotomy, immediate mesenteric reperfusion, and central aortic repair.
Methods: We retrospectively reviewed patients with acute aortic dissection with a preoperative diagnosis of mesenteric malperfusion who were treated between August 2011 and November 2022.
A Rare Case of Superior Mesenteric Artery Thrombosis With Gangrenous Bowel in a Patient With Mitral Valve Replacement in a Hypocoagulable State.
Cureus
November 2024
General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.
Acute thromboembolism of the superior mesenteric artery (SMA) causing mesenteric ischemia has a grave prognosis with high mortality rates. Its rarity and non-specific symptoms often lead to delayed diagnosis and increased morbidity. Early signs can include pain out of proportion to physical findings, with abdominal distension, tenderness, and guarding appearing only in later stages when bowel necrosis has occurred.
View Article and Find Full Text PDFSpontaneous transvaginal evisceration of small intestine in a case of long-standing uterine and rectal prolapse.
BMJ Case Rep
December 2024
Department of Surgery, Post Graduate Institute of Medical Education and Research and Capital Hospital, Bhubaneswar, Odisha, India
Spontaneous transvaginal small bowel evisceration, without recent trauma or surgery, is extremely rare. Complications include bowel obstruction, perforation, gangrene, septicaemia and death, requiring urgent surgical intervention. We report a case of a woman in her late 60s, who presented with 70-75 cm of small intestine eviscerated through the vagina, alongside a long history of uterine and rectal prolapse.
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