Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Laser localization with soft‑channel minimally invasive surgery in cerebral hemorrhage.
Exp Ther Med
March 2025
Department of Neurosurgery, Nanchuan Hospital of Chongqing Medical University, Chongqing 408400, P.R. China.
The aim of the present study was to evaluate the efficacy and safety of laser localization combined with soft-channel minimally invasive surgery (MIS) for the treatment of cerebral hemorrhage, and to develop stereotactic alternatives that are cost-effective, safe and precise for underdeveloped regions. To meet this aim, 60 patients with cerebral hemorrhage were randomly assigned to the control group (n=30) or the study group (n=30). The patients in the study group were treated with laser localization combined with soft-channel MIS to remove the hematoma, whereas the control group was treated with YL-1 needle puncture to drain the intracranial hemorrhage.
View Article and Find Full Text PDFIncreasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.
Fluids Barriers CNS
January 2025
Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven - University of Leuven, O&N II Herestraat 49 box 820, 3000, Leuven, Belgium.
Background: Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT) by targeting nutrient receptors to shuttle protein therapeutics over the blood-brain barrier (BBB) along with their endogenous cargos. While higher brain exposure is achieved with RMT, the timeframe is short due to rather fast brain clearance.
View Article and Find Full Text PDFPhysicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps.
ACS Appl Mater Interfaces
January 2025
University of California, Berkeley─University of California, San Francisco Graduate Program in Bioengineering, San Francisco, California 94158, United States.
Neutrophil extracellular traps (NETs) are networks of decondensed chromatin, histones, and antimicrobial proteins released by neutrophils in response to an infection. NET overproduction can cause an exacerbated hyperinflammatory response in a variety of diseases and can lead to host tissue damage without clearance of infection. Nanoparticle drug delivery is a promising avenue for creating materials that can both target NETs and deliver sustained amounts of NET-degrading drugs to alleviate hyperinflammation.
View Article and Find Full Text PDFReview of Indian studies on environmental impact assessment.
Integr Environ Assess Manag
January 2025
Department of Architecture and Planning, National Institute of Technology Patna, Patna, India.
Environmental clearance in India is a legal instrument that determines potential environmental implication of organized projects in India. It entails an assessment of sensitive projects, focal points, and proposals that have potential and likely effects on social, environmental, and economic matters before they are commenced. The intended goal of this procedure is to detect negative effects on local societies, the environment in this case, so as to foster sustainable development.
View Article and Find Full Text PDFStrengthening community actions to improve diabetes mellitus care optimising public health facilitators.
BMC Health Serv Res
January 2025
Department of Population and Behavioural Sciences, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
Background: Diabetes mellitus is the second leading cause of death in South Africa, and almost 90,000 people died from diabetes-related causes in the year 2019. This study aimed to investigate facilitators that can be harnessed to strengthen community actions and barriers that should be redressed in structured public health and health promotion programs for people with diabetes mellitus at a primary healthcare level.
Methods: An exploratory qualitative study was conducted using face-to-face interviews among 20 conveniently sampled participants.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!