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Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer.
Cancer Immunol Res
September 2024
Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Article Synopsis
- * Research using a mouse model revealed that mast cells (MCs) produce a protein called osteopontin (OPN), which helps inhibit NEPC growth through TNFα production when triggered by NEPC cells.
- * The study identified syndecan-1 (SDC1) as a specific ligand for NEPC that activates this protective pathway, suggesting MCs could be a target for new therapies and SDC1 might serve as a biomarker for early detection of NEPC.
Expression of Calcitonin Gene-Related Peptide and Calcitonin Receptor-like Receptor in Colorectal Adenocarcinoma.
Int J Mol Sci
April 2024
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Colorectal cancer is one of the most widespread types of cancer that still causes many deaths worldwide. The development of new diagnostic and prognostic markers, as well as new therapeutic methods, is necessary. The calcitonin gene-related peptide (CGRP) neuropeptide alongside its receptor calcitonin receptor-like receptor (CRLR) could represent future biomarkers and a potential therapeutic target.
View Article and Find Full Text PDFThe Potential of Salivary Biomarkers in Early Detection of Pancreatic Ductal Adenocarcinoma: A Systematic Review.
Cureus
February 2024
Internal Medicine, King Edward Medical University, Lahore, PAK.
Pancreatic ductal adenocarcinoma (PDAC) is a formidable global health concern with a dire prognosis, highlighting the critical need for early detection strategies. This systematic review delves into the potential of salivary biomarkers as a non-invasive means for identifying PDAC at its incipient stages. Saliva's proximity to the circulatory system enables the detection of tumor-derived biomolecules, making it an ideal candidate for mass screening.
View Article and Find Full Text PDFImplementation of endometrial cancer molecular subtyping into a hybrid community-academic practice.
Am J Clin Pathol
July 2024
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, US.
Objectives: We sought to confirm utility of our institution's modified Proactive Molecular Risk Classifier for Endometrial Cancer protocol in our daily practice, which includes mismatch repair (MMR), p53, and L1 cell adhesion molecule (L1CAM) immunohistochemistry with in-house next-generation sequencing for POLE, TP53, and CTNNB1.
Methods: We conducted a retrospective review of all patients in our institution who underwent primary endometrial carcinoma resection from the year prior to protocol implementation (PRE; October 1, 2020, to September 30, 2021) through first year of implementation (POST; October 1, 2021, to September 30, 2022) to compare the distribution of molecular and traditional staging factors using GOG-249 criteria to assign clinical risk.
Results: In total, 136 of 260 PRE patients were classified as clinically low risk (LR), of whom 31 were MMR deficient.
PDGFRβ targeted innovative imaging probe for pancreatic adenocarcinoma detection.
Talanta
April 2023
State Key Laboratory of Natural Medicine, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing, 211198, China. Electronic address:
The 5-year survival rate for pancreatic adenocarcinoma (PA) is less than 10%, making it one of the most lethal forms of cancer. Early-stage diagnosis and resection of the incipient lesions could increase the 4-year survival rate of PA up to 78%. Platelet-derived growth factor receptor β (PDGFRβ), an oncogenic key regulator for migration, proliferation and angiogenesis of cancer cells, has been proved to be aberrantly expressed in the majority of PA.
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