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SARS-CoV-2 transmission dynamics in Mozambique and Zimbabwe during the first 3 years of the pandemic.
R Soc Open Sci
January 2025
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
The 2019 emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread created a public health emergency of international concern. However, the impact of the pandemic in Sub-Saharan Africa, as documented in cases, hospitalizations and deaths, appears far lower than in the Americas, Europe and Asia. Characterization of the transmission dynamics is critical for understanding how SARS-CoV-2 spreads and the true scale of the pandemic.
View Article and Find Full Text PDFLong-term dynamics of placozoan culture: emerging models for population and space biology.
Front Cell Dev Biol
January 2025
Departments of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
As the simplest free-living animal, (Placozoa) is emerging as a powerful paradigm to decipher molecular and cellular bases of behavior, enabling integrative studies at all levels of biological organization in the context of metazoan evolution and parallel origins of neural organization. However, the progress in this direction also depends on the ability to maintain a long-term culture of placozoans. Here, we report the dynamic of cultures over 11 years of observations from a starting clonal line, including 7 years of culturing under antibiotic (ampicillin) treatment.
View Article and Find Full Text PDFCovariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI.
CPT Pharmacometrics Syst Pharmacol
January 2025
Pharmacokinetics Dynamics and Metabolism/Translational Medicine and Early Development, Sanofi R&D Montpellier, Montpellier, France.
A growing number of covariate modeling methods have been proposed in the field of popPK modeling, but limited information exists on how they all compare. The objective of this study was to perform a systematic review of all popPK covariate modeling methods, focusing on assessing the existing knowledge on their performances. For each method of each article included in this review, evaluation setting, performance metrics along with their associated values, and relative computational times were reported when available.
View Article and Find Full Text PDF[Clinical and epidemiological indicators of stroke during the COVID-19 pandemic and in the post-COVID period in the Moscow region].
Zh Nevrol Psikhiatr Im S S Korsakova
January 2025
Vladimirskii Moscow Regional Research and Clinical Institute, Moscow, Russia.
Objective: To analyze the dynamics of clinical and epidemiological indicators of stroke and the features of providing specialized care to patients in the Moscow region in the period 2019-2023.
Material And Methods: Mortality rates, the average annual population, and the number of deaths in one-year age groups were analyzed based on the «Brief Nomenclature of Causes of Death» by ROSSTAT and the database of the Registry Office of the Moscow Region. Depersonalized data on deceased individuals aged 18 years and older were obtained from this database, including codes and names of diseases or conditions specified in Parts I and II of the medical death certificate, age, sex, and place of death for the period 2019-2023.
Frankenstein matrices: Among-population life history variation affects the reliability and predictions of demographic models.
J Anim Ecol
January 2025
Conservation Biology, Institute for Ecology and Evolution, University of Bern, Bern, Switzerland.
Population matrix models are routinely used to study the demography of wild populations and to guide management choices. When vital rates are unknown for a specific population or life history stage, researchers often replace them with estimates from other populations of the same species. Such 'hybrid' matrices might ignore among-population life history variation and lead to incorrect inferences.
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