On the basis of data from literature the number of different normal structural variants of each human chromosome is calculated. Assuming independent combination of chromosome variants, the number of possible combinations of variants of all 22 pairs of autosomes and the probability of an individual to be hormozygous for the most frequent variants of all the autosome pairs simultaneously are estimated. The results obtained show that nearly each individual possesses a unique karyotype--a unique set of properties of chromosome heterochromatic regions.

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