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Characterization of L-amino Acid Oxidase Derived from Venom: Procoagulant and Anticoagulant Activities.
Int J Mol Sci
September 2019
Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Snake venom enzymes of the L-amino acid oxidase (LAAO) class are responsible for tissue hemorrhage, edema, and derangement of platelet function. However, what role, if any, these flavoenzymes play in altering plasmatic coagulation have not been well defined. Using coagulation kinetomic analyses (thrombelastograph-based), it was determined that the LAAO derived from venom displayed a procoagulant activity associated with weak clot strength (no factor XIII activation) similar to thrombin-like enzymes.
View Article and Find Full Text PDFBiochemical, mechanical, and morphological properties of a completely autologous platelet-rich wound sealant.
Blood Coagul Fibrinolysis
June 2012
Department of Surgery, Medical School of Nanjing University, China.
The optimal composition of fibrin sealant preparations is not known. We, therefore, sought to construct a series of sealants from autologous components and compare their functioning to Bioseal a commonly used sealant. Characteristics of the platelet-rich plasma, cryoprecipitate, and thrombin were determined and compared to commercial glue from composition, function, and microscopy aspects.
View Article and Find Full Text PDFPotential role of the dynamic properties of whole blood coagulation in assessment of dosage requirements in haemophilia.
Haemophilia
July 2003
Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry, University Hospital Skejby, Aarhus N, Denmark.
In the clinical setting, patients suffering from haemophilia are classified according to the residual level of the deficient coagulation factor. Patients suffering from the severe form of haemophilia (critical factor level <0.01 IU mL-1) display some heterogeneity in their tendency to bleeding despite the uniform factor level.
View Article and Find Full Text PDFChanges of biochemical markers and functional tests for clot formation during long-haul flights.
Thromb Res
October 2002
Department for General and Surgical Intensive Care Medicine, Clinic for Anaesthesia and Intensive Care Medicine, The Leopold-Franzens-University of Innsbruck, A-6020 Innsbruck, Austria.
Introduction: Long-haul flights have been suggested to be associated with an increased risk for thromboembolic events. Until now, changes in the coagulation system during an actual flight have not been investigated.
Materials And Methods: To explore whether any changes occur in the coagulation system during a real long-haul flight molecular markers for coagulation and fibrinolysis were measured in 20 volunteers (10 subjects with a low and 10 with a moderate risk for venous thromboembolism (VTE)) during and after a return flight from Vienna to Washington.
Laboratory assays for the evaluation of recombinant hirudin.
Haemostasis
October 1991
Department of Thoracic Cardiovascular Surgery, Loyola University Medical Center, Maywood, Ill.
Several laboratory methods are available to measure the anticoagulant activity of recombinant hirudin (r-hirudin), a potent thrombin inhibitor. These assays include clot-based, amidolytic, immunologic and physicochemical techniques. Although r-hirudin, like heparin, is an effective anticoagulant, the mechanism of action of the two agents is different.
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