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Characterisation of the effects of the chemotherapeutic agent paclitaxel on neuropathic pain-related behaviour, anxiodepressive behaviour, cognition, and the endocannabinoid system in male and female rats.
Front Pharmacol
January 2025
Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland.
Paclitaxel (PTX) is a commonly used chemotherapeutic drug, however, one of its major adverse effects is chronic neuropathic pain, with the incidence being higher in women than in men. The neurobiological mechanisms behind this sex difference are still largely unclear, and the endocannabinoid system, which exhibits sexual dimorphism and plays a key role in pain regulation, is a promising area for further studies. The present study aimed to characterise pain-, cognition-, anxiety-, and depression-related behaviours in male and female rats following PTX administration, and associated alterations in the endocannabinoid system.
View Article and Find Full Text PDFThe legalization of cannabis in several states across the US has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Rodent models are particularly valuable in this respect because they provide precise control over external variables. Previous rodent studies have found age and sex differences in response to injected Δ -tetrahydrocannabinol (THC), the major psychoactive component of cannabis.
View Article and Find Full Text PDFMicrostructural Characteristics of Damaged Hot Dry Rock Flow Network Stimulated by Cryogenic Liquid Nitrogen Shock.
ACS Omega
January 2025
School of Safety Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China.
Hot dry rock (HDR) geothermal development faces challenges due to the difficulty of stimulating fluid flow and heat-exchange fracture channels within deep, low-porosity, and low-permeability reservoirs. A liquid nitrogen cyclic cold shock method was proposed, using liquid nitrogen as a fracturing fluid. The large temperature difference between the liquid nitrogen and the hot rock induces thermal stress, forming a complex pore-fracture network.
View Article and Find Full Text PDFImproving Glycemic Control via Heat Therapy in older adults at risk for Alzheimer's Disease (FIGHT-AD): a pilot study.
J Appl Physiol (1985)
January 2025
University of Kansas Alzheimerșs Disease Research Center, University of Kansas Medical Center, Fairway, KS, USA.
Impaired glycemic control increases the risk for type 2 diabetes (T2D) and Alzheimer's Disease (AD). Heat therapy (HT), via hot water immersion (HWI), has shown promise in improving shared mechanisms implicated in both T2D and AD, like blood glucose regulation, insulin sensitivity, and inflammation. The potential for HT to improve brain health in individuals at risk for AD has not been examined.
View Article and Find Full Text PDFProgram temperature-controlled drying: An effective way to improve the quality of hot-air dried shiitake mushrooms.
J Food Sci
January 2025
Key Laboratory of Agro-food Quality and Safety of Ministry of Agriculture and Rural Affairs, Institute of Agricultural Quality Standard and Testing Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
This study applied program temperature-controlled drying (PTCD) to optimize the hot-air drying process for shiitake mushrooms, adjusting the drying temperature based on activity changes of γ-glutamyl transpeptidase (γ-GTase) and cysteine sulfoxide lyase (C-S lyase). Compared with constant temperature drying, PTCD (ST_75 and ST_150) significantly enhanced the umami and aroma profiles and sulfur compounds, increasing the levels of key flavor compounds such as glutamic acid and 5'-GMP. Moreover, PTCD improved rehydration capacity (515.
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