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Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway.
Int J Biol Sci
December 2024
Division of Pharmacology and Traditional Chinese Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan.
Ferroptosis, a mode of cell death characterized by iron-dependent phospholipid peroxidation, has a substantial therapeutic potential for the treatment of various cancers. This study investigated the effects of trifluoperazine (TFP), an FDA-approved drug traditionally utilized for mental health disorder, on oral cancer cells, with a particular focus on the mechanisms involved in its potential anti-tumor properties. Our findings indicate that TFP significantly elevates the levels of lipid-derived reactive oxygen species (ROS) and induces ferroptotic cell death in oral cancer cells through pathways involving autophagy, the SLC7A11/GPX4 axis, and mitochondrial damage.
View Article and Find Full Text PDFMeta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design.
J Tissue Eng
November 2024
Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Non-healing bone defects are a pressing public health concern accounting for one main cause for decreased life expectancy and quality. An aging population accompanied with increasing incidence of comorbidities, foreshadows a worsening of this socio-economic problem. Conventional treatments for non-healing bone defects prove ineffective for 5%-10% of fractures.
View Article and Find Full Text PDFA bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors.
Glia
February 2025
Glial Cell Biology Lab, Achucarro Basque Center for Neuroscience, Leioa, Spain.
Phagocytosis is an indispensable function of microglia, the brain professional phagocytes. Microglia is particularly efficient phagocytosing cells that undergo programmed cell death (apoptosis) in physiological conditions. However, mounting evidence suggests microglial phagocytosis dysfunction in multiple brain disorders.
View Article and Find Full Text PDFCrosstalk of methylglyoxal and calcium signaling in maize (Zea mays L.) thermotolerance through methylglyoxal-scavenging system.
J Plant Physiol
December 2024
School of Life Sciences, Yunnan Normal University, Kunming, 650092, PR China; Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Kunming, 650092, PR China; Key Laboratory of Biomass Energy and Environmental Biotechnology, Yunnan Province, Yunnan Normal University, Kunming, 650092, PR China. Electronic address:
Article Synopsis
- Methylglyoxal (MG) and calcium ions (Ca) were found to enhance thermotolerance in maize seedlings when exposed to heat stress, significantly increasing the survival percentage compared to control seedlings.
- The study showed that the effectiveness of MG in improving thermotolerance was reduced when various calcium inhibitors were applied, which suggests that calcium signaling plays a role in MG's effects.
- Both MG and Ca were shown to up-regulate various enzymes involved in detoxifying MG, indicating a collaborative effect between MG and Ca in enhancing the plant's ability to withstand stress conditions.
Trifluoperazine effect on human sperm: The accumulation of reactive oxygen species and the decrease in the mitochondrial membrane potential.
Reprod Toxicol
December 2024
Institute of Biomedical Innovation and School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China. Electronic address:
A strong link between antipsychotic drug use and reduced human sperm quality has been reported. Trifluoperazine (TFP), a commonly used antipsychotic, is now being explored for anticancer applications. Although there are hints that TFP might affect the male reproductive system, its impact on human sperm quality remains uncertain.
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