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Impact of cell geometry, cellular uptake region, and tumour morphology on Ac and Lu dose distributions in prostate cancer.
EJNMMI Phys
November 2024
Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.
Background: Radiopharmaceutical therapy with Ac- and Lu-PSMA has shown promising results for the treatment of prostate cancer. However, the distinct physical properties of alpha and beta radiation elicit varying cellular responses, which could be influenced by factors such as tumour morphology. In this study, we use simulations to examine how cell geometry, region of pharmaceutical uptake within the cell to model different internalization fractions, and the presence of tumour hypoxia and necrosis impact nucleus absorbed doses and dose heterogeneity with Ac and Lu.
View Article and Find Full Text PDFcharacterization of [I]HY-3-24, a selective ligand for the dopamine D3 receptor.
Front Neurosci
April 2024
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Introduction: Dopamine D3 receptor (D3R) ligands have been studied for the possible treatment of neurological and neuropsychiatric disorders. However, selective D3R radioligands for binding studies have been challenging to identify due to the high structural similarity between the D2R and D3R. In a prior study, we reported a new conformationally-flexible benzamide scaffold having a high affinity for D3R and excellent selectivity vs.
View Article and Find Full Text PDFDecreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density.
Cerebellum
June 2024
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Objective: Despite being one of the most prevalent neurological diseases, the pathophysiology of essential tremor (ET) is not fully understood. Neuropathological studies have identified numerous degenerative changes in the cerebellum of ET patients, however. These data align with considerable clinical and neurophysiological data linking ET to the cerebellum.
View Article and Find Full Text PDFEffect of Selective Lesions of Nucleus Accumbens µ-Opioid Receptor-Expressing Cells on Heroin Self-Administration in Male and Female Rats: A Study with Novel Knock-in Rats.
J Neurosci
March 2023
Intramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, Maryland, 21224
The brain µ-opioid receptor (MOR) is critical for the analgesic, rewarding, and addictive effects of opioid drugs. However, in rat models of opioid-related behaviors, the circuit mechanisms of MOR-expressing cells are less known because of a lack of genetic tools to selectively manipulate them. We introduce a CRISPR-based knock-in transgenic rat that provides cell type-specific genetic access to MOR-expressing cells.
View Article and Find Full Text PDFSomatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.
J Am Coll Cardiol
January 2023
Section of Cardiorespiratory Medicine, University of Cambridge, Cambridge, United Kingdom; Vascular Sciences, National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address:
Background: Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures.
Objectives: We aimed to investigate somatostatin receptor 2 (SST) as a novel inflammation-specific molecular imaging target in LVV.
Methods: In a prospective, observational cohort study, in vivo arterial SST expression was assessed by positron emission tomography/magnetic resonance imaging (PET/MRI) using Ga-DOTATATE and F-FET-βAG-TOCA.
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