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Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.
ACS Nano
January 2025
Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.
View Article and Find Full Text PDFTOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway.
Sci Rep
January 2025
Departamento Biología Experimental, Universidad de Jaén, Paraje Las Lagunillas S/N E23071, Jaén, Spain.
In this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition. Specifically, we focus on the spontaneous ability of cells to bypass or override this checkpoint, referred to as checkpoint adaptation. Some factors involved in adapting to this checkpoint are p53 and MCPH1.
View Article and Find Full Text PDFRussell's viper bite induced cortical sinus thrombosis and diffuse alveolar haemorrhage.
BMJ Case Rep
January 2025
Emergency Medicine, All India Institute of Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India.
Snakebites are critical medical emergencies that significantly contribute to emergency department visits during monsoon seasons. This case report details a patient who experienced simultaneous arterial and venous thrombosis of major intracranial vessels due to venom-induced consumptive coagulopathy. Additionally, the patient developed diffuse alveolar haemorrhage (DAH), highlighting the severe impact of these uncommon complications on prognosis.
View Article and Find Full Text PDFSodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats.
Ecotoxicol Environ Saf
January 2025
Liaoning Province Key Laboratory for phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shengyang, PR China. Electronic address:
Aim: Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride. Sodium butyrate (NaB), a short-chain fatty acid produced in the intestinal tract, maintains normal mitochondrial function in vivo and reduces liver inflammation and oxidative stress.
View Article and Find Full Text PDFAn untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells.
PLoS One
January 2025
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Aflatoxin B1 (AFB1) is a class 1 carcinogen and mycotoxin known to contribute to the development of hepatocellular carcinoma (HCC), growth impairment, altered immune system modulation, and malnutrition. AFB1 is synthesized by Aspergillus flavus and is known to widely contaminate foodstuffs, particularly maize, wheat, and groundnuts. The mechanism in which AFB1 causes genetic mutations has been well studied, however its metabolomic effects remained largely unknown.
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